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Last Updated: 3 months ago

Possible Interaction: Ethanol and Nalmefene

supplement:

Ethanol

Research Papers that Mention the Interaction

RESULTS Datasets from 18 participants were available and showed that in the presence of the al ohol infusion, n al mefene si gnificantly reduced the BOLD response in the striatal region of interest compared with placebo.
Biological Psychiatry  •  2017  |  View Paper
Nalmefene and naltrexone are used to block the effects of narcotics and alcohol.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences  •  2011  |  View Paper
In vitro experiments indicate that NX and NF inhibit TLR4 activation upon LPS or EtOH stimulation.
Alcoholism, clinical and experimental research  •  2017  |  View Paper
It is possible that nalmefene may attenuate withdrawal-induced increases in ethanol consumption by modulation of dopamine transmission through KORs.
International journal of molecular sciences  •  2016  |  View Paper
Nalmefene is an opioid antagonist which as a once-a-day tablet formulation has recently been approved for reducing ethanol intake in alcoholic subjects.
Journal of controlled release : official journal of the Controlled Release Society  •  2016  |  View Paper
Nalmefene and CTOP/naltrindole dose-dependently reduced ethanol self-administration in nondependent and dependent animals, whereas nor-BNI selectively attenuated ethanol self-administration in ethanol-dependent animals without affecting the self-administration of nondependent animals.
Neuropharmacology  •  2011  |  View Paper
However, in ethanol-dependent animals, nalmefene was significantly more effective in suppressing ethanol intake than naltrexone.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  •  2008  |  View Paper
The results demonstrated that when responding maintained by both EtOH and saccharin are matched at basal levels, unilateral (1–60 μg) or bilateral (0.5–10 μg) microinjections of nalmefene into the NACC produced selective dose-dependent reductions on responding maintained by EtOH.
Neuropsychopharmacology  •  2004  |  View Paper
Naltrexone (10 to 40 mg/kg) and nalmefene (1.5 to 3.0 mg/kg), given 8 to 24 hr before the test session, reduced control levels of responding maintained by EtOH by 82%.
These data demonstrate that, under a variety of experimental conditions, nalmefene is an effective antagonist of responding maintained by EtOH and lend support to clinical reports that nalmefene may function as an alternative pharmacotherapy to naltrexone to reduce EtOH-motivated behavior and prevent relapse.
Alcoholism, clinical and experimental research  •  1998  |  View Paper
Nalmefene , an opioid antagonist, dose-relatedly decreased intakes of ES , and was effective across days of injections.
Alcohol  •  1991  |  View Paper
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