Possible Interaction: Ethanol and Nalmefene

“ Nalmefene , as an opioid receptor modulator, could pharmacologically support the reduction of drinking by reducing the (anticipated) rewarding effects of alcohol and expanding the range of treatment options.”

“ Nalmefene increased brain activation in areas responsible for empathy, social cognition and behavior, which might help alleviating the reinforcing properties of alcohol.”

“RESULTS Datasets from 18 participants were available and showed that in the presence of the al ohol infusion, n al mefene si gnificantly reduced the BOLD response in the striatal region of interest compared with placebo.”

“ Nalmefene and naltrexone are used to block the effects of narcotics and alcohol.”

“In vitro experiments indicate that NX and NF inhibit TLR4 activation upon LPS or EtOH stimulation.”

“It is possible that nalmefene may attenuate withdrawal-induced increases in ethanol consumption by modulation of dopamine transmission through KORs.”

“ Nalmefene is an opioid antagonist which as a once-a-day tablet formulation has recently been approved for reducing ethanol intake in alcoholic subjects.”

“ Nalmefene and CTOP/naltrindole dose-dependently reduced ethanol self-administration in nondependent and dependent animals, whereas nor-BNI selectively attenuated ethanol self-administration in ethanol-dependent animals without affecting the self-administration of nondependent animals.”

“However, in ethanol-dependent animals, nalmefene was significantly more effective in suppressing ethanol intake than naltrexone.”

“The results demonstrated that when responding maintained by both EtOH and saccharin are matched at basal levels, unilateral (1–60 μg) or bilateral (0.5–10 μg) microinjections of nalmefene into the NACC produced selective dose-dependent reductions on responding maintained by EtOH.”