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Last Updated: 2 years ago

Possible Interaction: Ethanol and NADH

supplement:

Ethanol

supplement:

NADH

Research Papers that Mention the Interaction

Ethanol stimulates NADH production and thereby increases the rate of chloral hydrate reduction to trichloroethanol by liver alcohol dehydrogenase.
Clinical pharmacology and therapeutics  •  1972  |  View Paper
Prolonged administration of alcohol (within 2 months) caused an intensification of glycolysis and an increase in NADH cytochrome C oxidoreductase pathway with preferable oxidation of succinate and activation of cytochrome C oxidase; the phenomenon appears to be an adaptation to chronic "alcohol hypoxia".
Voprosy meditsinskoi khimii  •  1977  |  View Paper
Similarly, ethanol metabolism alters the ratio of NAD+ to reduced NAD ( NADH ) and promotes the formation of reactive oxygen species and acetate, all of which impact epigenetic regulatory mechanisms.
Alcohol research : current reviews  •  2013  |  View Paper
Ethanol metabolism also causes an increase in the free reduced nicotinamide adenine dinucleotide ( NADH ) in cells, which might reasonably be expected to decrease the retinol oxidation rate by product inhibition of ADH isoforms.
Alcoholism, clinical and experimental research  •  2009  |  View Paper
In addition to the above, ethanol may also induce free radical formation via the reaction of aldehyde oxidase with acetaldehyde or NADH to generate oxyradicals via disturbance in the metabolism of the pro-oxidant iron, or via increased efflux from mitochondria following altered mitochondrial oxidative metabolism.
Adverse drug reactions and toxicological reviews  •  1999  |  View Paper
A factor which restricts ethanol metabolism is the reoxidation of a reduced form of nicotinamide dinucleotide ( NADH ) produced during ethanol oxidation to acetaldehyde by an alcohol dehydrogenase (ADH)-NADH system [6,7].
Journal of forensic sciences  •  1977  |  View Paper
That an alteration in the NADH NAD ratio occurs with ethanol ingestion can be indirectly inferred by the changes in serotonin, galactose, and norepinephrine metabolism.
Metabolism: clinical and experimental  •  1972  |  View Paper
The availability of unreduced NAD in the cell sap seems to be important10,11, because NADH competes with NAD for binding sites on the enzyme ADH and, in sufficient concentration, may inhibit the rate of ethanol dehydrogenation12.
Nature  •  1968  |  View Paper
It was suggested that ethanol increased NADH and decreased NAD such that 5-hydroxyindoleacetaldehyde-C 14 derived from the serotonin-C 14 was preferentially converted to 5-hydroxytryptophol-C 14 with a concomitant decrease in 5-HIAA-C 14 .
Life sciences  •  1967  |  View Paper
Chronic ethanol consumption induces the disturbances in cytoplasmic enzymes of neurons: increases the activity of type B monoamine oxidase, dehydrogenases of lactate and NADH and, especially, marker enzyme of lysosomes acid phosphatase as well as inhibits the activity of dehydrogenases of succinate and glucose-6-phosphate.
Alcohol and alcoholism  •  2015  |  View Paper
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