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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“These various effects can be explained by the increase in the hepatic nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide ratio secondary to the oxidation of ethanol via the alcohol dehydrogenase pathway.”
Effects of ethanol upon lipid metabolism“ Alcohol , by way of its primary metabolite, acetaldehyde, competitively inhibits nicotinamide-adenine Sinucleotide-linked aldehyde dehydrogenase and augments the formation of tetrahydropapaveroline in vitro.”
“Similarly, ethanol metabolism alters the ratio of NAD+ to reduced NAD (NADH) and promotes the formation of reactive oxygen species and acetate, all of which impact epigenetic regulatory mechanisms.”
“A factor which restricts ethanol metabolism is the reoxidation of a reduced form of nicotinamide dinucleotide (NADH) produced during ethanol oxidation to acetaldehyde by an alcohol dehydrogenase (ADH)-NADH system [6,7].”
“That an alteration in the NADH NAD ratio occurs with ethanol ingestion can be indirectly inferred by the changes in serotonin, galactose, and norepinephrine metabolism.”
“It was suggested that ethanol increased NADH and decreased NAD such that 5-hydroxyindoleacetaldehyde-C 14 derived from the serotonin-C 14 was preferentially converted to 5-hydroxytryptophol-C 14 with a concomitant decrease in 5-HIAA-C 14 .”
“In primary rat hepatocytes, ethanol exposure (25 mmol/L, 24 h) similarly decreased SIRT1 expression and NAD+ /NADH ratio (33%, P < 0.05; 32%, P < 0.01), and 0.1 μmol/L resveratrol treatment reversed these decreases and inhibited the expressions of ADH and CYP2E1.”
Resveratrol attenuates excessive ethanol exposure induced insulin resistance in rats via improving NAD+ /NADH ratio.“ Ethanol treatment also significantly increased the activity of nicotinamide adenine dinucleotide (NADPH) oxidase and the expression of NADPH oxidase-2 (Nox2).”
“Furthermore, it increased the pKa value of the group in the binary enzyme NAD+ complex that regulates the kon velocity of alcohol and alcohol‐competitive inhibitors.”
“ Ethanol feeding significantly increased liver steatosis and oxidative damage, compared with wild-type mice, and disrupted the ratio of nicotinamide adenine dinucleotide.”
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