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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
N-Methylscopolamine
Research Papers that Mention the Interaction
“Acute exposure of the … to 100 mM ethanol induced a decrease in [3H]N-methylscopolamine ([3H]NMS) binding at 30 seconds which was of lower magnitude and of shorter duration than the previously described ethanol-induced inhibition of the peak of carbachol-stimulated I(1,4,5)P3 formation.”
Effects of ethanol on phosphoinositide hydrolysis and muscarinic acetylcholine receptor number in SH-SY5Y cells.“ Ethanol exposure for 2 or 4 days also caused an increase in [3H]N-methylscopolamine and [3H]quinuclidinyl benzilate binding sites and elevation of [3H]pirenzepine binding, which indicated that the number of muscarinic M1 receptors is increased in ethanol-treated SH-SY5Y cells.”
“Compared to saline, both doses of scopolamine and methscopolamine induced a significant reduction in ethanol consumption in the P line of rats, and both antimuscarinic agents significantly increased water intake.”
“In contrast, scopolamine had relatively little effect on either ethanol or water intake in the NP line of rats, while methscopolamine tended to suppress both ethanol and water intake.”
Reduction in ethanol preference following injection of centrally and peripherally acting antimuscarinic agents.“Following exposure to 100 mM ethanol for 2 days, both [3H]N‐methylscopolamine binding and carbachol‐stimulated I(1,4,5)P3 formation were increased.”
Chronic effects of ethanol on muscarinic acetylcholine receptors are modulated by protein kinase C
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