Possible Interaction: Ethanol and N-Methyl-3,4-Methylenedioxyamphetamine

“After further controlling for co-use of alcohol with ecstasy , and the sub-acute effects of ecstasy on sleep, the sub-acute effect on mood remained marginally statistically signi.cant but the subacute effect on cognitive impairment did not.”

“ 3,4-Methylenedioxymethamphetamine (MDMA) is frequently consumed in association with alcohol.”

“Combined use of MDMA and alcohol causes dissociation between subjective and objective sedation.”

“ MDMA reversed the subjective sedation induced by alcohol but did not reduce drunkenness feelings.”

“Plasma concentrations of MDMA showed a 13% increase after the use of alcohol , whereas plasma concentrations of alcohol showed a 9 to 15% decrease after MDMA administration.”

“The combination of MDMA and ethanol caused the highest suppressive effect on CD4 T cells and increasing effect in NK cells.”

“Combined MDMA and alcohol produced the greatest suppressive effect on CD4 T-cell count and PHA-stimulated lymphoproliferation.”

“ Ethanol exposure enhanced the reinforcing effects of cocaine and MDMA in both groups when CPP was induced with a sub-threshold dose of the drugs.”

“Finally we discuss the mechanism of synergistic drug-interaction between MDMA and other abused substances including alcohol (ethanol) as well as application of this redox-based proteomics method in translational studies for developing effective preventive and therapeutic agents against MDMA-induced organ damage.”

“The possibility that EtOH may modify the pharmacokinetics and pharmadynamics of MDMA is of concern in terms of liability for misuse abuse.”

“In contrast, MDMA pharmacodynamics were affected: locomotor activity increased and body temperature decreased after concurrent exposure to MDMA and ethanol compared to lone MDMA exposure.”

“In summary, concurrent ethanol exposure appears to increase the risk for MDMA toxicity.”

“A 19‐year‐old woman with insulin‐dependent diabetes mellitus was found dead in bed having allegedly recently taken ecstasy and consumed alcohol.”

“The primary motivations for using MDMA included: (1) altering the effects of marijuana and alcohol ; (2) lasting longer sexually; (3) enhancing sexual pleasure; and (4) facilitating “freaky” sexual experiences.”