Possible Interaction: Ethanol and Muscimol

“Reduction of the action of ethanol of alpha-1 beta-2 gamma-2L cells occurred within 15 min and was near-maximal for 25 mM ethanol, whereas reduction of the actions of muscimol and flunitrazepam actions required hours of exposure and higher concentrations of ethanol.”

“Thus, the type of expression/assay system markedly affects the actions of ethanol on GABAA receptors and also influences the actions of muscimol and pentobarbital on this receptor.”

“Coapplication of muscimol and EtOH significantly increased the frequency of spontaneous IPSCs and EPSCs.”

“ResultsThe GABAA receptor agonist muscimol (1–10 ng/site) decreased ethanol intake dose-dependently, while administration of the GABAA receptor antagonist bicuculline (10–100 ng) had an opposite effect.”

“Baclofen dose-dependently increased binge-like ethanol intake, while both muscimol and THIP reduced ethanol intake.”

“In frontal cortex, PPII activity was inhibited by ethanol, NMDA and MK-801 with ethanol ; its mRNA levels were reduced by ethanol, MK-801 and muscimol (NMDA and picrotoxin reverted ethanol's inhibition).”

“The antidepressant like effect of ethanol was potentiated by GABA(A) receptor agonist, muscimol (0.5 mg/kg, i.p.),”

“An inhibitory action of ethanol on responses to GABA and muscimol , which was also influenced by baclophen, was observed from some Purkinje neurons.”

“ Ethanol (50 and 100 mM) exhibited high efficacy on muscimol responses , a 4- to 5-fold potentiation, respectively, of muscimol (10 microM) alone.”

“At 10-min postinjection, muscimol (0.01 and 0.04 micrograms/microliter) potentiated (> 80% ethanol lever responding) the discriminative stimulus properties of a dose of ethanol (0.5 g/kg) that alone produced only partial generalization.”