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Last Updated: 2 years ago

Possible Interaction: Ethanol and Ms-275

supplement:

Ethanol

drug:

Ms-275

Research Papers that Mention the Interaction

MS-275 also diminished both the motivation to consume ethanol (25% decrease), relapse (by about 50%) and postponed reacquisition after abstinence.
Recent work in rodents has shown that systemic administration of pan HDAC class I and II inhibitors, TSA and N-hydroxy-N-phenyl-octanediamide [SuberoylAnilide Hydroxamic Acid] (SAHA), and of the more selective inhibitor (mainly HDAC1 and HDAC9) MS-275 , decrease binge-like alcohol drinking in mice.
Biologie aujourd'hui  •  2017  |  View Paper
Additionally, the dose-response curve test indicated that MS-275 has a U-shape effect on ethanol self-administration with the dose of 500 µM as the most efficient dose.
Furthermore, we showed that MS-275 also diminished the motivation to consume ethanol (25% decrease), and finally, we demonstrated that MS-275 reduced relapse (by about 50%) and postponed reacquisition even when the treatment was stopped.
Here, we examined whether intra-cerebroventricular administration of MS-275 , a class I-specific histone deacetylase inhibitor, could alter ethanol self-administration, motivation to consume ethanol, and relapse in heavy drinking rats.
Second, we observed that MS-275 decreases ethanol self-administration by about 75%.
The international journal of neuropsychopharmacology  •  2015  |  View Paper