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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2012 | View Paper
“Pretreatment with moxonidine (0.01, 0.1, and 1.0 mg/kg, subcutaneously), but not clonidine (0.3, 1.0, and 3.0 mg/kg, subcutaneously), significantly attenuated the ethanol withdrawal-induced elevation of the acoustic startle response.”
“After the combined administration of ethanol and moxonidine the pathological changes were bigger than those found in animals which received alcohol alone.”
“The results might indicate that moxonidine increased cytotoxic activity of ethanol on several organs in rats.”