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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Moxidectin
Research Papers that Mention the Interaction
“Investigations using recombinant cell models and animal models of alcohol drinking have reported that IVM, ABM, and MOX , but not SEL, were able to antagonize the inhibitory effects of ethanol on P2X4Rs in vitro and reduce ethanol intake in vivo.”
Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders“Previously, we reported that avermectin compounds (Ivermectin [IVM] and moxidectin [MOX]) significantly reduced ethanol intake in male and female mice.”
A novel pharmacotherapy approach using P-Glycoprotein (PGP/ABCB1) efflux inhibitor combined with ivermectin to reduce alcohol drinking, preference in mice.“Further, multi‐day administration of MOX (2.5 mg/kg; intraperitoneal injection) for 5 consecutive days significantly reduced ethanol intake in both the 24‐h‐two‐bottle choice and Drinking‐in‐the‐Dark paradigms in female mice.”
“ MOX potentiates ATP‐gated P2X4R function and antagonize the inhibitory effects of ethanol on the receptor.”
“Notably in both male and female mice, MOX significantly reduced ethanol intake starting approximately 4 h post‐injection.”
“Using a 24‐h‐two‐bottle choice paradigm, MOX significantly reduced ethanol intake in a dose dependent manner in both male and female C57BL/6J mice, respectively (1.25–7.5 mg/kg) and (1.25–10 mg/kg).”
“Using a Xenopus oocyte expression system, we found that MOX significantly potentiated P2X4 receptor (P2X4R) function and antagonized the inhibitory effects of ethanol on ATP‐gated currents in P2X4Rs.”
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