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Last Updated: 24 days ago

Possible Interaction: Ethanol and Moxidectin

supplement:

Ethanol

Research Papers that Mention the Interaction

Investigations using recombinant cell models and animal models of alcohol drinking have reported that IVM, ABM, and MOX , but not SEL, were able to antagonize the inhibitory effects of ethanol on P2X4Rs in vitro and reduce ethanol intake in vivo.
Psychopharmacology  •  2018  |  View Paper
Further, multi‐day administration of MOX (2.5 mg/kg; intraperitoneal injection) for 5 consecutive days significantly reduced ethanol intake in both the 24‐h‐two‐bottle choice and Drinking‐in‐the‐Dark paradigms in female mice.
MOX potentiates ATP‐gated P2X4R function and antagonize the inhibitory effects of ethanol on the receptor.
Notably in both male and female mice, MOX significantly reduced ethanol intake starting approximately 4 h post‐injection.
Using a 24‐h‐two‐bottle choice paradigm, MOX significantly reduced ethanol intake in a dose dependent manner in both male and female C57BL/6J mice, respectively (1.25–7.5 mg/kg) and (1.25–10 mg/kg).
Using a Xenopus oocyte expression system, we found that MOX significantly potentiated P2X4 receptor (P2X4R) function and antagonized the inhibitory effects of ethanol on ATP‐gated currents in P2X4Rs.
Neuropharmacology  •  2017  |  View Paper
Previously, we reported that avermectin compounds (Ivermectin [IVM] and moxidectin [MOX]) significantly reduced ethanol intake in male and female mice.
Alcohol  •  2020  |  View Paper