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Last Updated: 3 months ago

Possible Interaction: Ethanol and Morphine

supplement:

Ethanol

Research Papers that Mention the Interaction

When morphine was administered with ethanol , similar AEs were observed (dizziness, headache, somnolence, nausea, and vomiting), but these were sometimes more frequent compared with those observed with either drug alone.
Human psychopharmacology  •  2014  |  View Paper
CONCLUSIONS The results indicate that ethanol inhibits two steps in the heroin metabolism; the hydrolysis of 6-MAM to morphine , and the glucuronidation of morphine to M3G and M6G.
Forensic science international  •  2014  |  View Paper
A pharmacokinetic interaction between ethanol and morphine is suggested from in vitro studies, but to our knowledge not documented in vivo.
The ratios between M6G and morphine was also lower in the ethanol positive cases, i.e. mean 0.62 (95 % CI 0.42–… mean 0.96 (95 % CI 0.89–1.02) in group 2 (p = 0.001).ConclusionsThis study indicated that the metabolism of morphine may … ethanol , resulting ….
European Journal of Clinical Pharmacology  •  2013  |  View Paper
Moreover we have shown that cocaine, alcohol and nicotine significantly enhance (125)I-trace labeled morphine release from invertebrate ganglia and human white blood cells.
Neuro endocrinology letters  •  2008  |  View Paper
The results presented here suggest that morphine may be of limited use in inhibiting nociceptive TRPV1 responses that have been sensitised by exposure to ethanol.
European journal of pain  •  2008  |  View Paper
Ethanol , being a respiratory depressant, combined with morphine drastically increases the risk of rapid death due to respiration failure.
Arhiv za higijenu rada i toksikologiju  •  2007  |  View Paper
Morphine was the single isolate in only 21 cases giving a median blood free morphine (BFM) of … were the primary isolates [Formula: see text] the median BFM was 0.37 mg/L, and when morphine … alcohol [Formula: see text] the median BFM was … between these groups ( [Formula: see text] ).
Journal of clinical forensic medicine  •  2004  |  View Paper
The authors conclude that the presence of ethanol in the blood together with morphine drastically augments the risk of rapid death from respiration arrest.
Sudebno-meditsinskaia ekspertiza  •  2002  |  View Paper
Opioid agonists, like morphine , also alter ethanol consumption.
Alcoholism, clinical and experimental research  •  2001  |  View Paper
We found significant negative … between concentrations of ethanol and morphine (a heroin metabolite) in blood (R2 = 0.11, P = 0.0001 for log10-transformed variables) as well as between concentrations of blood ethanol and bile morphine (R2 = 0.16, P = 0.0001 for log10 bile morphine versus blood morphine).
Journal of forensic sciences  •  1990  |  View Paper
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