Possible Interaction: Ethanol and Monoamine Oxidase Inhibitors

“Pretreatment of hepatocytes with N-acetyl cystein (ROS reducer), or dietary antioxidants (quercetin, reserveratrol), or NADPH (reduced nicotinamide adenine dinucleotide phosphate) oxidase inhibitor apocynin, significantly reduced ethanol (50 mM, 24 h) induced increases in ROS and H3AcK9.”

“The reversible MAO-A inhibitor, befloxatone (0.3-3 mg/kg), and the irreversible MAO-A inhibitor , clorgyline (10-30 mg/kg), also reduced ethanol self-administration.”

“In the presence of a potent type A MAO inhibitor (harmaline, 10 mg/kg maternal weight 2 hr before fetal delivery) co-treatment with ethanol was found to result in a 60% elevation of whole fetal brain norepinephrine levels.”

“The turnover of cerebral 5-HT, determined from rates of increase in concentration of 5-HT or of decrease in concentration of 5-HIAA after the administration of a monoamine oxidase inhibiter , was modestly decreased during ethanol intoxication.”