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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Minocycline
Research Papers that Mention the Interaction
“In mice, minocycline also reduces ethanol intake, attenuates ethanol-induced conditioned place preference, and inhibits ethanol-induced microglial activation and pro-inflammatory cytokine release.”
Targeting neuroinflammation with minocycline in heavy drinkers“In comparison, minocycline attenuated alcohol‐induced neurodegeneration; elevating expression levels of P‐CREB and BDNF and inhibited alcohol induced histopathological changes in both dentate gyrus (DG) and CA1 of hippocampus.”
The possible role of CREB‐BDNF signaling pathway in neuroprotective effects of minocycline against alcohol‐induced neurodegeneration: molecular and behavioral evidences“CONCLUSION Mi ocycline at tenuates alcohol withdrawal anxiety and disrupts alc ohol relapse. ”
“Together, these results suggest that minocycline may ameliorate ethanol neurotoxicity in the developing by alleviating GSK3&bgr;‐mediated neuroinflammation.”
“ Minocycline reduced alcohol , but also water, intake regardless of LPS pretreatment.”
“ Minocycline reversed these cellular effects of alcohol.”
“Only minocycline and tigecycline significantly reduced EtOH drinking, and doxycycline showed a strong effect size trend toward reduced drinking.”
“We, and others, have shown that the tetracycline drugs, minocycline and doxycycline, reduced ethanol (EtOH) drinking in mice.”
“We have previously shown the immunomodulatory drugs, minocycline and tigecycline, were effective in reducing ethanol (EtOH) consumption in both the 2-bottle choice and drinking-in-the-dark paradigms.”
“ Minocycline , a neuroimmune modulator, reduced high ethanol ( EtOH ) drinking in adult, but not adolescent, mice as predicted a priori.”
“However, minocycline led to greater motor impairment induced by alcohol , implicating different mechanisms in alcohol-induced sedation and motor impairment.”
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