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Possible Interaction: Ethanol and Mianserin

supplement:

Ethanol

Research Papers that Mention the Interaction

During conditioning, ethanol produced increases in locomotor activity that were reduced by mianserin.
However, mianserin enhanced the acquisition of ethanol preference, whereas mianserin alone did not produce either place preference or aversion.
Behavioural pharmacology  •  1996  |  View Paper
Considering these antecedents, we explored modulation of the acute stimulating effect of ethanol (2.5g/kg) by two anxiolytic drugs, Mianserin (2.5 or 5mg/kg) and Ondansetron (1 or 3mg/kg).
Mianserin attenuated the stimulating effect of ethanol at a dose that did not affect locomotor activity in water-controls, likely acting through 5-HT2 receptors, while Ondansetron, a 5-HT3 antagonist, did not affect this response.
Pharmacology Biochemistry and Behavior  •  2011  |  View Paper
In contrast, both single dose and repeated administration of mianserin prevents increased locomotor activity of animals observed after ethanol (2.5 mgkg(-1)).
Mianserin administered as a single dose of 5 mgkg(-1) was found to decrease LD(50) of ethanol and its ED(50) in rota-rod test.
Mianserin administered as a single dose of 5 or 20 mgkg(-1) prolongs ethanol sleeping time in mice but given daily for 14 days has no influence on this time.
Pharmacological research  •  2002  |  View Paper
However, when administered concurrently with ethanol treatment, mianserin significantly antagonized the reductions in cortical GRE-DNA binding and in GR protein expression in cortical, PVN, and central, but not medial and basolateral, amygdaloid structures during ethanol withdrawal.
On the other hand, mianserin treatment along with ethanol administration significantly decreased the hippocampal GRE-DNA binding and GR protein expression in various hippocampal structures during ethanol withdrawal.
The Journal of pharmacology and experimental therapeutics  •  2002  |  View Paper
Desipramine, mianserin and alaproclate also increased ethanol plasma levels initially, but to a lesser extent.
Journal of Neural Transmission  •  1980  |  View Paper