Possible Interaction: Ethanol and Metyrapone

“Elevation of HDL cholesterol (40%-70% over control) was observed when the cells were exposed to an ethanol concentration of > or = 10 mM. Metyrapone , which inhibited the MEOS, was capable of blocking the induction of apoAI caused by ethanol treatment.”

“By contrast, 50-87% of the oxidation of ethanol by these cells was inhibited by carbon monoxide, metyrapone and SKF-525A, all three of which are known to inhibit various species of microsomal cytochrome P-450.”

“When administered finasteride (100 mg/kg) or metyrapone (50 mg/kg), all mice reduced their EtOH intake while increasing their water consumption.”

“In these cells, the decrease in presence of combined ethanol and metyrapone was 95% (low toluene concentrations).”

“The fluid intake of male Wistar rats with simultaneous access to water and 6% ethanol was determined between 0900 … covering > 60% of their daily fluid consumption in the form of ethanol), two injections with the corticosterone synthesis inhibitor metyrapone (50 mg/kg) at … consecutive days significantly reduced ethanol preference ….”