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Last Updated: 3 months ago

Possible Interaction: Ethanol and Methotrexate

supplement:

Ethanol

Research Papers that Mention the Interaction

The admonition to patients to refrain entirely from consumption of alcohol while taking methotrexate may be unnecessary.
Bulletin of the Hospital for Joint Disease  •  2013  |  View Paper
Because the combination of methotrexate and ethanol played a significant role in the immunodeficiency of the patient, their effect on the immune system is addressed.
Laeknabladid  •  2007  |  View Paper
Methotrexate use increased the likelihood of alcohol screening (43% [33/76] vs 26% 123/871; P = .02).
Archives of pediatrics & adolescent medicine  •  2000  |  View Paper
Heavy users of alcohol should not receive long-term methotrexate therapy.
The American journal of medicine  •  1991  |  View Paper
The high incidence of fibrosis is attributed to synergism between methotrexate and other hepatotoxic factors, particularly alcohol , the use of a baseline biopsy to identify subsequent changes, and the early detection of fibrosis by sensitive histological techniques.
The Journal of investigative dermatology  •  1982  |  View Paper
The 14 patients with cirrhosis when compared to patients with normal histology (9 patients), had taken an … of MTX at the latest liver biopsy, but had consumed a statistically significant higher amount of alcohol (p less ….05) during MTX therapy and also tended to … (p less than 0.006).
Acta pathologica et microbiologica Scandinavica. Section A, Pathology  •  1977  |  View Paper
Ethanol (3g/dl) has a mild inhibitory effect on pteroylglutamate and amethopterin transport.
The Journal of pharmacology and experimental therapeutics  •  1981  |  View Paper
The stimulatory effect was specific to 5-methyltetrahydrofolate since ethanol inhibited uptake of folate and methotrexate.
Archives of biochemistry and biophysics  •  1979  |  View Paper