supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Ethanol
drug:
Methotrexate
Research Papers that Mention the Interaction
“The admonition to patients to refrain entirely from consumption of alcohol while taking methotrexate may be unnecessary.”
Update on methotrexate as the anchor drug for rheumatoid arthritis.“Because the combination of methotrexate and ethanol played a significant role in the immunodeficiency of the patient, their effect on the immune system is addressed.”
“ Methotrexate use increased the likelihood of alcohol screening (43% [33/76] vs 26% 123/871; P = .02).”
“Heavy users of alcohol should not receive long-term methotrexate therapy.”
“The high incidence of fibrosis is attributed to synergism between methotrexate and other hepatotoxic factors, particularly alcohol , the use of a baseline biopsy to identify subsequent changes, and the early detection of fibrosis by sensitive histological techniques.”
“The 14 patients with cirrhosis when compared to patients with normal histology (9 patients), had taken an … of MTX at the latest liver biopsy, but had consumed a statistically significant higher amount of alcohol (p less ….05) during MTX therapy and also tended to … (p less than 0.006).”
“ Ethanol (3g/dl) has a mild inhibitory effect on pteroylglutamate and amethopterin transport.”
Characteristics of the transport of pteroylglutamate and amethopterin in rat jejunum.“The stimulatory effect was specific to 5-methyltetrahydrofolate since ethanol inhibited uptake of folate and methotrexate.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback