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Last Updated: 2 years ago

Possible Interaction: Ethanol and Metformin



Research Papers that Mention the Interaction

Chronic or acute intake of large amounts of alcohol may potentiate the effect of metformin on lactate metabolism.
Annals of Internal Medicine  •  2002  |  View Paper
Thus, our findings suggest that metformin has antioxidant and anxiolytic effects and may partially reverse the neurotoxic effects induced by ethanol.
Journal of Molecular Neuroscience  •  2020  |  View Paper
ResultsOral administration of the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves (500 mg/kg body weight) and metformin (150 mg/kg) significantly reduced blood glucose level (P < 0.05), improved serum lipid profiles, liver enzymes and kidney functions in diabetic rats after 14 days.
BMC Complementary and Alternative Medicine  •  2015  |  View Paper
The histopathological score portrayed that the noxious effect of ethanol is prevented in the liver of moderate- and high-dose metformin , whereas the renal histological scores were unchanged in all the groups including ethanol control.
Iranian biomedical journal  •  2012  |  View Paper
Furthermore, Met and TQ maintained normal physiological mitochondrial transmembrane potential (ΔψM), which is typically lowered by ethanol exposure.
BMC Neuroscience  •  2011  |  View Paper
Instead, the protective effects of metformin correlated with complete prevention of the upregulation of plasminogen activator inhibitor (PAI)-1 caused by ethanol.
Metformin treatment significantly blunted the ethanol effect by >60%.
Gastroenterology  •  2006  |  View Paper
These results indicate that: (1) doses of DMBG which produce hypoglycemia are associated with lactic acidosis, and (2) this effect of DMBG can be markedly potentiated by ethanol.
Research communications in chemical pathology and pharmacology  •  1981  |  View Paper
Studies have suggested the individual role of probiotics and metformin Met in protecting intestinal barrier function from injuries induced by ethanol.
Mediators of inflammation  •  2021  |  View Paper