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Last Updated: 2 years ago

Possible Interaction: Ethanol and Metformin

supplement:

Ethanol

Research Papers that Mention the Interaction

Chronic or acute intake of large amounts of alcohol may potentiate the effect of metformin on lactate metabolism.
Annals of Internal Medicine  •  2002  |  View Paper
Thus, our findings suggest that metformin has antioxidant and anxiolytic effects and may partially reverse the neurotoxic effects induced by ethanol.
Journal of Molecular Neuroscience  •  2020  |  View Paper
ResultsOral administration of the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves (500 mg/kg body weight) and metformin (150 mg/kg) significantly reduced blood glucose level (P < 0.05), improved serum lipid profiles, liver enzymes and kidney functions in diabetic rats after 14 days.
BMC Complementary and Alternative Medicine  •  2015  |  View Paper
The histopathological score portrayed that the noxious effect of ethanol is prevented in the liver of moderate- and high-dose metformin , whereas the renal histological scores were unchanged in all the groups including ethanol control.
Iranian biomedical journal  •  2012  |  View Paper
Furthermore, Met and TQ maintained normal physiological mitochondrial transmembrane potential (ΔψM), which is typically lowered by ethanol exposure.
BMC Neuroscience  •  2011  |  View Paper
Instead, the protective effects of metformin correlated with complete prevention of the upregulation of plasminogen activator inhibitor (PAI)-1 caused by ethanol.
Metformin treatment significantly blunted the ethanol effect by >60%.
Gastroenterology  •  2006  |  View Paper
These results indicate that: (1) doses of DMBG which produce hypoglycemia are associated with lactic acidosis, and (2) this effect of DMBG can be markedly potentiated by ethanol.
Research communications in chemical pathology and pharmacology  •  1981  |  View Paper
Studies have suggested the individual role of probiotics and metformin Met in protecting intestinal barrier function from injuries induced by ethanol.
Mediators of inflammation  •  2021  |  View Paper