Possible Interaction: Ethanol and Metformin

“Chronic or acute intake of large amounts of alcohol may potentiate the effect of metformin on lactate metabolism.”

“Thus, our findings suggest that metformin has antioxidant and anxiolytic effects and may partially reverse the neurotoxic effects induced by ethanol.”

“ResultsOral administration of the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves (500 mg/kg body weight) and metformin (150 mg/kg) significantly reduced blood glucose level (P < 0.05), improved serum lipid profiles, liver enzymes and kidney functions in diabetic rats after 14 days.”

“The histopathological score portrayed that the noxious effect of ethanol is prevented in the liver of moderate- and high-dose metformin , whereas the renal histological scores were unchanged in all the groups including ethanol control.”

“Furthermore, Met and TQ maintained normal physiological mitochondrial transmembrane potential (ΔψM), which is typically lowered by ethanol exposure.”

“Instead, the protective effects of metformin correlated with complete prevention of the upregulation of plasminogen activator inhibitor (PAI)-1 caused by ethanol.”

“ Metformin treatment significantly blunted the ethanol effect by >60%.”

“These results indicate that: (1) doses of DMBG which produce hypoglycemia are associated with lactic acidosis, and (2) this effect of DMBG can be markedly potentiated by ethanol.”

“Studies have suggested the individual role of probiotics and metformin Met in protecting intestinal barrier function from injuries induced by ethanol.”