Possible Interaction: Ethanol and Meprobamate

“ Ethanol ingestion significantly retarded the disappearance of pentobarbital and meprobamate from the blood in human volunteer subjects and rats.”

“In vitro, ethanol inhibited the metabolism of meprobamate by rat liver slices, which indicates a direct effect on hepatic drug metabolism.”

“Analysis of single psychoactive drug cases and single-drug-plus-ethanol cases shows that, in the presence of ethanol , the toxic blood concentration of imipramine, amytriptyline, meprobamate , thioridazine, morphine, propoxyphene, methaqualone, and all barbiturates was decreased by an average of 50%.”

“Both sets of analyses found a complex interaction between the pattern of abosorption and elimination of meprobamate and dose of alcohol.”

“In E-V, 2.5 and 5.…, the combination of 28 mg of meprobamate per … of alcohol per kg resulted in significantly lower BMC (7.83 and 12.63 mug per 100 ml) … meprobamate with the other doses of alcohol (14.23 and 20.02 mug per 100 ml).”

“It was considered that by long-term ethanol administration the permeability of blood-brain barrier to meprobamate might be accelerated, resulting in an increase in BrMC.”

“Also, elimination of meprobamate from brain in rats was fairly accelerated by long-term ethanol administration at the daily dose of 0.4g.”

“Thus, accelerative effect of long-term ethanol administration on meprobamate metabolism may be greatly related to ethanol dosage and it is considered that the accelerative effects reach maximum at blood ethanol concentrations more than 1mg/ml.”

“In the simultaneous administration of meprobamate and ethanol to rabbits, the blood meprobamate concentration (BMC) increased greatly when the maximum blood ethanol concentration (BECmax) exceeded 1.0 mg/ml.”

“It was indicated that the effect of ethanol on reinforcement of meprobamate activity would appear strongly by potentiation effect.”

“Simultaneous acute administration of ethanol (2g/kg) with psychotropic drugs such as chlordiazepoxide (librium), diazepam (valium), chlorpromazine (thorazine) or meprobamate (equanil) to pregnant or non-pregnant rats led to a decrease in the blood alcohol clearance rates.”

“Addition of ethanol in vitro was found to inhibit the microsomal metabolism of a variety of drugs such as meprobamate , aminopyrine, pentobarbital and zoxazolamine.”

“In vivo acute administration of ethanol also resulted in decreased whole body metabolism of meprobamate , aminopyrine, pentobarbital, zoxazolamine and aniline.”

“Abstract … of ethanol ranging from 10 to 12 g/kg for 1 month in either high-fat adequate protein (HFAP) or low-fat … (LFHP) liquid diets resulted in significant increases in liver weight, microsomal protein and microsomal metabolism of aminopyrine, zoxazolamine, aniline and meprobamatc , when related to … body weight.”