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Last Updated: 3 years ago

Possible Interaction: Ethanol and Memantine



Research Papers that Mention the Interaction

Memantine increased the dissociative effects of alcohol , without altering its sedative, stimulant, and overall intoxicating effects.
Psychopharmacology  •  2004  |  View Paper
Our results showed that memantine (25 mg/kg) abolished ethanol self‐administration in ND rats and reduced by half the one of PD rats during acute withdrawal.
This suggests that memantine probably act by potentiating the pharmacological effect of ethanol but not by reducing motivation for ethanol.
Addiction biology  •  2015  |  View Paper
Thus, memantine may be neuroprotective when administered during ethanol withdrawal.
Alcoholism, clinical and experimental research  •  2014  |  View Paper
These results demonstrate that an acute injection of memantine specifically reduces EtOH self‐administration and motivation to consume EtOH for at least 30 hours.
We found that memantine decreased EtOH self‐administration and motivation to consume EtOH 6 and 30 hours post‐injection.
We hypothesized that memantine could decrease ethanol (EtOH) consumption via activation of the BNDF signalling pathway.
Addiction biology  •  2014  |  View Paper
The uncompetitive NMDA receptor antagonists memantine and ketamine dose-dependently reduced ethanol drinking in alcohol-preferring rats; while memantine had a preferential effect on alcohol over saccharin, ketamine reduced responding for both solutions.
Behavioural Brain Research  •  2013  |  View Paper
ResultsModerate doses of memantine , neramexane, and MTEP interacted with ethanol to increase the frequency of attack bites while ketamine did not.
Psychopharmacology  •  2012  |  View Paper
CONCLUSION These results indicate that a single me antine ad ministration during eth anol wi thdrawal can mitigate motor impairments but not spatial learning impairments or overactivity observed following a binge ethanol exposure during development in the rat.
Neurotoxicology and teratology  •  2011  |  View Paper
In conclusion, memantine may decrease ethanol consumption with fewer side effects than other NMDA receptor antagonists, such as phencyclidine (PCP), MK 801 and ketamine.
Memantine (10.0 mg/kg) partially reversed both the sedation and the reductions in locomotor activity induced by ethanol.
The results indicate that memantine dose-dependently decreased the amount of ethanol and proportion of ethanol to total fluids consumed daily, reaching 48% and 24%, respectively, at the highest dose.
Basic & clinical pharmacology & toxicology  •  2010  |  View Paper
Results showed that one N-methyl-D-aspartate receptor (NMDAR) antagonist, memantine , but not another, dextromethorphan, potentiated the ataxic but not hypothermic or sedative/hypnotic effects of ethanol.
Neuropsychopharmacology  •  2009  |  View Paper
Memantine increased locomotion during alcohol SIP (25 mg/kg) and during water SIP (5 and 25 mg/kg).
Psychopharmacology  •  2006  |  View Paper
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