Possible Interaction: Ethanol and Mecamylamine

“Even when the lower BALs were taken into account, mecamylamine reduced ratings of stimulation after alcohol ( Addiction Research Center Inventory A scale).”

“In laboratory animals, mecamylamine , a central nicotinic receptor antagonist, reduces the consumption of and preference for alcohol.”

“It was hypothesized that mecamylamine (7.5 and 15 mg) would attenuate the stimulant-like subjective effects of alcohol (0.8 g/kg) and decrease the self-reported desire to consume additional alcohol beverages.”

“RESULTS Me amylamine at tenuated the stimulant and euphoric effects of alc ohol an d reduced the self-reported desire to consume additional alcohol beverages.”

“This study was conducted to test the hypothesis that, during the ascending limb of the blood alcohol concentration curve, mecamylamine would reduce the stimulating and pleasurable effects of an intoxicating dose of alcohol in humans.”

“Rat CT responses to ethanol are also partially inhibited by nAChR blockers, mecamylamine and dihydro-β-erythroidine.”

“The nAChR modulators: mecamylamine , dihydro-β-erythroidine, and CP-601932 (a partial agonist of the α3β4* nAChR), inhibited CT responses to nicotine, ethanol , and acetylcholine.”

“Pre-treatment with mecamylamine inhibited the rate-inhibiting properties of ethanol in the VTA, but not in the nAc.”

“Coinfusion with 200 μM mecamylamine (nACh antagonist) or 100 and 200 μM zacopride (5-HT3 receptor antagonist) blocked the observed nicotine enhancement of EtOH seeking.”

“For both rat strains, blood alcohol concentration in the mecamylamine pretreatment group was significantly less at this time interval by about 50-60 mg/dL, suggesting a mechanism whereby mecamylamine can mitigate some of the acute effects of alcohol (e.g., on VC components N39 and P46).”

“However, mecamylamine pretreatment reduced the effects of alcohol on components N39 and P46.”

“On separate days, either saline or mecamylamine was given 10 min prior to either saline or ethanol.”

“In addition, chronic administration of mecamylamine into ethanol diet-fed mice markedly attenuated the ethanol withdrawal sign scores, thus supporting the contention that nAChR is involved in ethanol dependence.”

“In conclusion, our results suggest that mecamylamine exhibited inhibitory effects on ethanol withdrawal signs which could be mediated through nAChR.”

“Results showed that acute administration of mecamylamine (1–4 mg/kg, intraperitoneally) dose-dependently attenuated ethanol withdrawal-induced signs, and these effects were comparable with those of diazepam (1–2 mg/kg, intraperitoneally).”

“However, intra-CA1 or -BLA microinjection of mecamylamine (1-4 microg/rat) reversed the response induced by the microinjection of nicotine (1 microg/rat, intra-CA1 or -BLA) plus ethanol (0.5 g/kg i.p.)”

“Moreover, intra-CA1 administration of nicotine plus ethanol increased the locomotor activity on the test day which was reversed by pretreatment with mecamylamine , while other treatments had no effect on locomotor activity.”