Possible Interaction: Ethanol and Magnesium

“There is evidence that magnesium deficit is involved in addiction to various addictive substances (heroin, morphine, cocaine, nicotine, alcohol , caffeine, and others).”

“A recent paper by Marrero and colleagues (2015) has linked 2 otherwise disparate findings, where EtOH exposure depletes magnesium , and where EtOH activates the BK-type fast, calcium-activated potassium channel (BK), within a common mechanism.”

“…,EtOH exposure has … to deplete magnesium , which has been observed in different tissues in preclinical models (although not tested in neurons) and in humans with alcohol use disorders (… fact, magnesium repletion has been considered as a therapy for some aspects of AUDs (see references in Marrero et al., 2015).”

“Evidence is reviewed that demonstrates that the dietary intake of Mg modulates the hypertensive actions of alcohol.”

“Previous literature identifies magnesium as an important cofactor in thiamine utilisation, which might also be compromised in alcohol dependent patients.”

“The magnitude of ethanol inhibition was significantly enhanced when recordings were carried out in media containing 1 mM magnesium.”

“Both serum levels of magnesium (in the first 6 hours) and urinary levels (in the first 12 hours) increased after the ingestion of alcohol.”

“Adjunction of magnesium 5 minutes before and 3 minutes after addition of ethanol permits to study the preventive and curative antagonistic effects of magnesium on ethanol action.”

“Besides magnesium significantly (p less than 0.01) induces both preventive and curative antagonistic effects on the decrease of trans amniotic conductance induced by ethanol.”

“Furthermore membranous antagonistic effects between magnesium and ethanol only involve 4 components among the 7 ways affected by ethanol.”

“ Magnesium significantly increases the whole group of the 10 components of trans-amniotic conductance while ethanol only decreases 7 of them.”

“Thirdly though magnesium is a real membranous antagonist of ethanol , it cannot be described as an ideal antagonist.(ABSTRACT TRUNCATED AT 400 WORDS)”

“Although the production of this deficiency is not entirely clear and is undoubtedly influenced by diet and gastrointestinal loss, of particular significance is the demonstration by McCollister, Funk and Lewis’ that the urinary excretion of magnesium is increased following ingestion of alcohol.”

“ Ethanol (10%) ingestion enhanced the hepatic lipid peroxidation and decreased the calcium and magnesium content of blood and liver.”

“ Magnesium decreases the intensity of some drug-induced dependences (e.g. opiates, nicotine, cocaine, amphetamine, ethanol , etc.).”