Possible Interaction: Ethanol and Lysine

“In silico modeling suggested that ethanol alters the dynamics for assembling Aβ by disrupting a critical salt bridge between residues Asp 23 and Lys 28, required for amyloid dimerization.”

“Recent evidence suggests that ethanol and its metabolites can selectively increase histone H3 acetylation at lysine 9 (H3AcK9) residue in rat hepatocytes.”

“Of interest is the observation that ethanol caused selective acetylation of Lys 9 of histone 3 in the hepatocyte nucleus.”

“However, the inhibitory effects of ethanol were reduced by expression of an NR1 C0 domain deletion mutant (NR1Δ839–863), truncation mutant (NR1858stop), or a triple-point mutant (Arg to Ala, Lys to Ala, and Asn to Ala at 859–861) previously shown to significantly reduce calcium-dependent inactivation.”

“Prior chronic ethanol consumption depressed (p less than 0.05) placental uptake of AIB (38%), cycloleucine (45%), Ala (35%), Leu (25%), and Lys (34%).”

“ L-Lysine increased the oral LD50 of ethanol , while diethanolamine-rutin decreased the intraperitoneal LD50 of ethanol.”

“Furthermore, ethanol and acetaldehyde induced lysine residue and microtubules hyperacetylation.”

“Results: … that ethanol treatment of P7 mice … of H4 on lysine 8 (H4K8ace) at CB1R exon1, CB1R binding as well as the CB1R agonist-stimulated GTPγS binding in the hippocampus and … brain regions that are vulnerable to ethanol at P7 and are important for memory formation and storage, respectively.”

“We found that a low dose of ethanol induces mild neurodegeneration in P7 mice, enhances specific acetylation of H3 on lysine 14 (H3K14ace) at G9a exon1, G9a protein levels, augments the dimethylation of H3K9 and H3 lysine 27 (H3K27me2).”

“In our previous studies, we found that alcohol selectively increased acetylation of histone H3 at lysine 9 (H3K9) and enhanced the expression of heart development-related genes in cardiac progenitor cells.”