Possible Interaction: Ethanol and Losartan

“ Ethanol withdrawal increased catalase activity in the LV and losartan attenuated this response.”

“ Ethanol withdrawal reduced the concentration of hydrogen peroxide (H2O2) in the LV and this response was prevented by losartan.”

“ Losartan prevented ethanol withdrawal-induced increase in superoxide anion (O2•-) production in the left ventricle (LV).”

“ Ethanol induced systemic and vascular oxidative stress (aorta and MAB) and these effects were prevented by losartan.”

“The decrease on plasma and vascular nitrate/nitrite (NOx) levels induced by ethanol was prevented by losartan.”

“The increase in blood pressure induced by ethanol was prevented by losartan (10mg/kg/day; p.o.”

“The AT1 subtype receptor is involved because pretreatment with losartan , an AT1 antagonist, prevents Ang II, diazepam, and ethanol impairment of LTP as well as their effects on behavior.”

“Results of our previous research in rats demonstrate the following: (a) Angiotensin II (Ang II) inhibits long term potentiation (LTP) in dentate granule … antagonist; (b) both ethanol and diazepam inhibit LTP induction and this inhibition can be blocked by losartan; (c) impairment of air righting by ethanol … losartan : (d) ….”

“In addition, we had shown that ethanol intoxicating effects on air righting can be significantly reduced by losartan.”

“Low doses of ethanol , 1 g/kg, and DZ, 1 mg/kg, appear to be equivalent in the impairment of air righting; and the effects of both drugs were blocked by losartan , in a dose-dependent way.”

“We had previously discovered that both diazepam (DZ) and ethanol inhibited long-term potentiation (LTP) in medial perforant path-dentate granule cell synapses and the inhibition was mediated by angiotensin II (Ang II) because it could be blocked by pretreatment with losartan , an Ang II AT1 receptor antagonist.”

“Ang II impairment of retention and ethanol inhibition of LTP can both be blocked by pretreatment with losartan.”

“… losartan … ethanol intoxication measured in terms of the aerial righting reflex, the purpose of the present study was to assess the effects of 2.0 g/… an eight-arm radial maze, and then to determine the effectiveness of losartan in reducing the impairment of the learning and memory process.”

“Results show a clear intoxicating effect of ethanol on the aerial righting reflex that was blocked significantly by losartan in a dose-dependent way.”

“The … of EtOH intoxication effects on the aerial righting reflex supports results of our previous studies on the effects of EtOH on open field behavior, AII … an inhibitory shock avoidance response, and AII inhibition of hippocampal granule cell long-term potentiation, all of which can be blocked by losartan.”

“ANG II has been shown to mediate impairment of the retention of an inhibitory shock avoidance response and to be involved in ethanol and diazepam inhibition of dentate gyrus LTP, all of which can be blocked by losartan.”

“Our present results demonstrate that the combined inhibitory effects of EtOH and DZ on LTP induction are also blocked by losartan.”

“Results demonstrate that losartan can effectively block some of the intoxicating effects of low doses of ethanol , 2 g/kg PO or IP.”