Possible Interaction: Ethanol and Long Chain Fatty Acid

“By contrast, in rodent hepatocytes and in human hepatoma cell lines, ethanol up-regulates the LCFA uptake Vmax.”

“These results support the hypothesis that effects of ethanol on the developing brain may be modified by the availability of an exogenous supply of long chain fatty acids.”

“In strains not selected for superior tolerance to ethanol, dietary ethanol promoted a loss of long-chain fatty acids in membrane lipids.”

“… ethanol … chain length of fatty acid was decreased [hexanoate (6:0) = 23 mumol g-1 h-1; octanoate (8:0) = 55 mumol g-1 h-1; decanoate (10:…; oleate (18:1) = 60 mumol g-1 h-1; erucate (22:3) = 22 mumol g-1 h-1] from 12:0.”

“The results suggest that in the hamster long-term voluntary ethanol intake alters specific long chain fatty acids , but that erythrocyte membrane integrity and tissue lipid composition were not compromised.”

“It is suggested that ethanol inhibits fatty acid oxidation in hepatocytes by competitive substrate oxidation, resulting in an increased availability of long-chain free fatty acids ; this thereby enhances esterification, leading to accumulation of liver triglyceride.”

“Increasing alcohol concentrations resulted in a decrease in the degree of saturation of recovered fatty acid alcohol esters and a slight increase in the fatty acid chain length.”

“A partial correlation analysis controlling for performance of the lines on ethanol‐free medium revealed a strong association between the degree of long chain fatty acid content and line survival when ethanol was fed.”