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Last Updated: 3 years ago
supplement:
Ethanol
supplement:
Linoleic Acid
Research Papers that Mention the Interaction
“Fatty acid profiling demonstrated that alcohol feeding dramatically increased hepatic unsaturated long chain fatty acyl species, particularly linoleic acid and oleic acid, which was attenuated by dietary MCT.”
Preservation of hepatocyte nuclear factor-4α contributes to the beneficial effect of dietary medium chain triglyceride on alcohol-induced hepatic lipid dyshomeostasis in rats.“ Ethanol (… blood linoleic acid (LA) levels; (2) blocks conversion of LA and gamma-linolenic acid (GLA) to arachidonic acid (AA), as well as alpha-linolenic acid (ALA) …), by inhibiting delta-6 and delta-5 desaturases; and (3) enhances the conversion of dihomo-gamma-linolenic acid (DGLA) to PGE1 [ 1].”
“ Ethanol exposure also promoted triacylglycerol accumulation when the cells were incubated with linoleic acid.”
“ Ethanol has three main known … PG metabolism: it reduces blood linoleic acid levels and induces or exaggerates EFA deficiency states; it blocks metabolism of linoleic acid to EFA metabolites which are … in brain structure; and it enhances conversion of the linoleic acid metabolite, dihomo-gamma-linolenic acid, to PGE1.”
“Both ethanol and carbon tetrachloride impair desaturation of linoleic acid and dihomo-gamma-linolenic acid and this appears to be relevant to the pathogenesis of fatty liver from two points of view.”
“The linoleic acid : arachidonic acid ratio (18:2/20:4) and the saturation:unsaturation ratio were also increased in PI and PS in membranes from alcohol animals.”
“In the red blood cell membranes, ethanol affected the levels of the octadecenoic acids (18:1) which rose, and linoleic acid (18:2) which fell.”
“The … alcohol to rat and human liver slices depressed the formation of 14 CO … from palmitic acid-1- 14 C, oleic acid-1- 14 C and linoleic acid-1- 14 C. The esterification to triglycerides and phospholipids was … and the formation of β-keto acids was decreased by alcohol.”
“Herein, we tested the hypothesis that a combination of ethanol and a diet rich in linoleic acid (LA) leads to the increased production of oxidized LA metabolites (OXLAMs), specifically 9- and 13-hydroxyoctadecadienoic acids (HODEs), which contribute to a hepatic proinflammatory response exacerbating liver injury.”
Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice.“The ethanol extract exhibited a concentration-dependent inhibition of linoleic acid oxidation in a thiocyanate assay system.”
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