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Last Updated: 2 years ago

Possible Interaction: Ethanol and Linoleic Acid




Linoleic Acid

Research Papers that Mention the Interaction

Fatty acid profiling demonstrated that alcohol feeding dramatically increased hepatic unsaturated long chain fatty acyl species, particularly linoleic acid and oleic acid, which was attenuated by dietary MCT.
Alcoholism, clinical and experimental research  •  2013  |  View Paper
Ethanol (… blood linoleic acid (LA) levels; (2) blocks conversion of LA and gamma-linolenic acid (GLA) to arachidonic acid (AA), as well as alpha-linolenic acid (ALA) …), by inhibiting delta-6 and delta-5 desaturases; and (3) enhances the conversion of dihomo-gamma-linolenic acid (DGLA) to PGE1 [ 1].
PLoS medicine  •  2006  |  View Paper
Ethanol exposure also promoted triacylglycerol accumulation when the cells were incubated with linoleic acid.
Hepatology  •  1999  |  View Paper
Ethanol has three main known … PG metabolism: it reduces blood linoleic acid levels and induces or exaggerates EFA deficiency states; it blocks metabolism of linoleic acid to EFA metabolites which are … in brain structure; and it enhances conversion of the linoleic acid metabolite, dihomo-gamma-linolenic acid, to PGE1.
Alcoholism, clinical and experimental research  •  1987  |  View Paper
Both ethanol and carbon tetrachloride impair desaturation of linoleic acid and dihomo-gamma-linolenic acid and this appears to be relevant to the pathogenesis of fatty liver from two points of view.
Alcoholism, clinical and experimental research  •  1987  |  View Paper
The linoleic acid : arachidonic acid ratio (18:2/20:4) and the saturation:unsaturation ratio were also increased in PI and PS in membranes from alcohol animals.
Life sciences  •  1985  |  View Paper
In the red blood cell membranes, ethanol affected the levels of the octadecenoic acids (18:1) which rose, and linoleic acid (18:2) which fell.
Biochemical pharmacology  •  1984  |  View Paper
The … alcohol to rat and human liver slices depressed the formation of 14 CO … from palmitic acid-1- 14 C, oleic acid-1- 14 C and linoleic acid-1- 14 C. The esterification to triglycerides and phospholipids was … and the formation of β-keto acids was decreased by alcohol.
Life sciences  •  1973  |  View Paper
Herein, we tested the hypothesis that a combination of ethanol and a diet rich in linoleic acid (LA) leads to the increased production of oxidized LA metabolites (OXLAMs), specifically 9- and 13-hydroxyoctadecadienoic acids (HODEs), which contribute to a hepatic proinflammatory response exacerbating liver injury.
The American journal of pathology  •  2017  |  View Paper
The ethanol extract exhibited a concentration-dependent inhibition of linoleic acid oxidation in a thiocyanate assay system.
Journal of agricultural and food chemistry  •  2002  |  View Paper
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