Possible Interaction: Ethanol and Lidocaine

“Furthermore, lidocaine reduced ethanol self‐administration, but the effect was fully attenuated by noradrenaline given directly in the pVTA.”

“The maximum flux (Jmax) was 1.6-1.8 fold lower for lidocaine applied in 50% ethanol , propylene glycol, isopropylalcohol and isopropylalcohol/isopropylmyristate.”

“The melting point of lidocaine was significantly lowered when mixed with thymol and/or aqueous ethanol.”

“Atropine or lidocaine significantly reversed the cytoprotection of 20% ethanol.”

“The local anaesthetic, lignocaine also inhibited the effect of ethanol on circular muscle.”

“Ongoing administration of ethanol decreased the dose of lidocaine required to produce sensory blockade, but this difference was not significant relative to the control group (i.e., the difference was significant within group but not across groups).”

“These results suggest that chronic ethanol intake produces tolerance to the local anesthetic effects of lidocaine.”

“Gastric mucosal lesions induced by 80% ethanol with 100 mM HCl on the ex vivo rat stomach were significantly reduced by lidocaine (2.2-4.4 mg/kg bolus followed by 66-132 micrograms/kg/min i. v. infusion).”

“ Ethanol in doses of 1.5–3 g/kg, given 1–3 hours previously, caused a significant prolongation of lidocaine narcosis.”

“Hence it remains to be shown, for instance, what role the inhibition or induction of drug-metabolizing enzymes by ethanol plays in the prolongation or shortening of lidocaine narcosis.”

“ Lidocaine narcosis was shortened by subchronic ethanol administration but this shortening was statistically significant only when ethanol was given continuously to rats in their drinking fluid.”

“A small but consistent synergism occurred between lidocaine and benzyl alcohol.”

“A lipophilic solvent, isostearyl alcohol which when replacing ethanol by 30%, slows the release rate and enhances the topical adsorption of lidocaine.”