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Last Updated: 3 years ago

Possible Interaction: Ethanol and Lidocaine



Research Papers that Mention the Interaction

Furthermore, lidocaine reduced ethanol self‐administration, but the effect was fully attenuated by noradrenaline given directly in the pVTA.
Addiction biology  •  2017  |  View Paper
The maximum flux (Jmax) was 1.6-1.8 fold lower for lidocaine applied in 50% ethanol , propylene glycol, isopropylalcohol and isopropylalcohol/isopropylmyristate.
BMC Veterinary Research  •  2014  |  View Paper
The melting point of lidocaine was significantly lowered when mixed with thymol and/or aqueous ethanol.
International journal of pharmaceutics  •  2001  |  View Paper
Atropine or lidocaine significantly reversed the cytoprotection of 20% ethanol.
Digestion  •  1996  |  View Paper
The local anaesthetic, lignocaine also inhibited the effect of ethanol on circular muscle.
Indian journal of physiology and pharmacology  •  1992  |  View Paper
Ongoing administration of ethanol decreased the dose of lidocaine required to produce sensory blockade, but this difference was not significant relative to the control group (i.e., the difference was significant within group but not across groups).
These results suggest that chronic ethanol intake produces tolerance to the local anesthetic effects of lidocaine.
Anesthesia and analgesia  •  1990  |  View Paper
Gastric mucosal lesions induced by 80% ethanol with 100 mM HCl on the ex vivo rat stomach were significantly reduced by lidocaine (2.2-4.4 mg/kg bolus followed by 66-132 micrograms/kg/min i. v. infusion).
Acta physiologica Hungarica  •  1989  |  View Paper
Ethanol in doses of 1.5–3 g/kg, given 1–3 hours previously, caused a significant prolongation of lidocaine narcosis.
Hence it remains to be shown, for instance, what role the inhibition or induction of drug-metabolizing enzymes by ethanol plays in the prolongation or shortening of lidocaine narcosis.
Lidocaine narcosis was shortened by subchronic ethanol administration but this shortening was statistically significant only when ethanol was given continuously to rats in their drinking fluid.
Acta pharmacologica et toxicologica  •  1976  |  View Paper
A small but consistent synergism occurred between lidocaine and benzyl alcohol.
Canadian journal of physiology and pharmacology  •  1975  |  View Paper
A lipophilic solvent, isostearyl alcohol which when replacing ethanol by 30%, slows the release rate and enhances the topical adsorption of lidocaine.
International journal of pharmaceutics  •  2010  |  View Paper
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