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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“A single injection of L-dopa tended to enhance ethanol withdrawal reactions and 5HTP tended to suppress it.”
Effects of brain biogenic amines on ethanol withdrawal reactions and the development of ethanol dependence in mice.“When L-dopa at 60 mg/Kg was administered to alcohol chronic rats, inhibition reached about 30%.”
“The same two TIQs have been detected … brain and urine of mammals administered alcohol and a second …—for example, L-dopa or pyrogallol; and it has been proposed that these Pictet–Spengler condensation products (of dopamine and dopaldehyde or acetaldehyde, respectively) may be responsible for addiction in alcoholism2–5.”
“ Chronic alcohol drinking led to a decrease in dopamine and DOPAL (a direct dopamine metabolite and a high-affinity ADH substrate) levels in the striatum, while immunization neutralized this effect.”
Active immunization against serum alcohol dehydrogenase normalizes brain dopamine metabolism disturbed during chronic alcohol consumption.“The in vitro study revealed that in presence of l-menthol (2%, W/W), ethanol (20 and 40%, V/V) accelerated transdermal penetration of l-dopa with an increase of its percentages.”
“Topical application of a dopamine agonist, bromocriptine, or L-beta-3,4-dihydroxyphenylalanine , significantly reduced the extent of damage induced by subsequent application of 70% ethanol.”
“Carlsson and Lindqvid demonstrated that the intraperitoneal administration of ethanol is associated with a significant increase in the accumulation of L-3,4dihydroxyphenylalanine (dopa) in the brain following inhibition of L-aromatic amino acid decarboxylase.”
“To explain this phenomenon the possibility might be considered that ethanol causes a decrease in the plasma concentration of other amino acids competing with L-dopa for the same carrier system (Oldendorf 1975; Pardridge & Oldendorf 1977; Wurtman & Fernstrom 1976; Carlsson & Lindqvist 1978).”
“We have recently reported that the passage of exogenously administered L-dopa through the blood-brain barrier in rat is increased after previous administration of ethanol (Eriksson et a1 1979).”
“Administration of L-DOPA and pCPA, together, produced a smaller augmentation of ethanol effects.”
“Pretreatment with L-DOPA produced a marked prolongation of ethanol narcosis with a concomitant large increase in whole brain dopamine (DA).”
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