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Last Updated: 2 years ago

Possible Interaction: Ethanol and Levodopa

supplement:

Ethanol

Research Papers that Mention the Interaction

A single injection of L-dopa tended to enhance ethanol withdrawal reactions and 5HTP tended to suppress it.
Japanese journal of pharmacology  •  1982  |  View Paper
When L-dopa at 60 mg/Kg was administered to alcohol chronic rats, inhibition reached about 30%.
Pharmacological research communications  •  1977  |  View Paper
The same two TIQs have been detected … brain and urine of mammals administered alcohol and a second …—for example, L-dopa or pyrogallol; and it has been proposed that these Pictet–Spengler condensation products (of dopamine and dopaldehyde or acetaldehyde, respectively) may be responsible for addiction in alcoholism2–5.
Nature  •  1977  |  View Paper
Chronic alcohol drinking led to a decrease in dopamine and DOPAL (a direct dopamine metabolite and a high-affinity ADH substrate) levels in the striatum, while immunization neutralized this effect.
Alcohol  •  2019  |  View Paper
The in vitro study revealed that in presence of l-menthol (2%, W/W), ethanol (20 and 40%, V/V) accelerated transdermal penetration of l-dopa with an increase of its percentages.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences  •  1998  |  View Paper
Topical application of a dopamine agonist, bromocriptine, or L-beta-3,4-dihydroxyphenylalanine , significantly reduced the extent of damage induced by subsequent application of 70% ethanol.
Gastroenterology  •  1989  |  View Paper
Carlsson and Lindqvid demonstrated that the intraperitoneal administration of ethanol is associated with a significant increase in the accumulation of L-3,4dihydroxyphenylalanine (dopa) in the brain following inhibition of L-aromatic amino acid decarboxylase.
Annals of the New York Academy of Sciences  •  1987  |  View Paper
To explain this phenomenon the possibility might be considered that ethanol causes a decrease in the plasma concentration of other amino acids competing with L-dopa for the same carrier system (Oldendorf 1975; Pardridge & Oldendorf 1977; Wurtman & Fernstrom 1976; Carlsson & Lindqvist 1978).
We have recently reported that the passage of exogenously administered L-dopa through the blood-brain barrier in rat is increased after previous administration of ethanol (Eriksson et a1 1979).
The Journal of pharmacy and pharmacology  •  1980  |  View Paper
Administration of L-DOPA and pCPA, together, produced a smaller augmentation of ethanol effects.
Pretreatment with L-DOPA produced a marked prolongation of ethanol narcosis with a concomitant large increase in whole brain dopamine (DA).
Pharmacology, biochemistry, and behavior  •  1973  |  View Paper