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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Levetiracetam
Research Papers that Mention the Interaction
“Conclusions Our data suggest that levetiracetam is not an appropriate treatment for non-treatment seeking alcohol abusers and can, in fact, increase their consumption of alcohol.”
The Anticonvulsant Levetiracetam Potentiates Alcohol Consumption in Non-Treatment Seeking Alcohol Abusers“Pretreatment with LEV reduced acute locomotor stimulation by 2.0 g/kg alcohol, attenuated the development of locomotor sensitization to alcohol with repeated exposure, and produced a shift in the dose-response curve for alcohol on BSR threshold without affecting maximum operant response rate (MAX).”
Levetiracetam Has Opposite Effects on Alcohol- and Cocaine-Related Behaviors in C57BL/6J Mice“Combined administration of ethanol and levetiracetam (200mg/kg) resulted in a markedly synergistic effect in the frontal cortex and the midbrain reticular formation.”
“Some elements of the … mechanism of action that levetiracetam has in common with ethanol , give rise to the question of whether there is an interaction between these two agents and whether there is any risk associated with the enhanced depressive effect of these agents on the central nervous system.”
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