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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Leukotriene C4
Research Papers that Mention the Interaction
“Using the calcium ionophore A23187 as stimulus, the leukotriene B4 (LTB4) and leukotriene C4 (LTC4) generation were dose-dependently impaired by ethanol.”
Ethanol affects leukotriene generation and leukotriene-induced functional responses in human polymorphonuclear granulocytes.“Various alcohol concentrations cause an increase in LTC4 and PGE2 in healthy volunteers; we observed no LTC4 increase in alcoholics and although PGE2 levels increased after 20% ethanol, they remained constant at higher ethanol concentrations.”
“Exposure of the rat gastric mucosa to ethanol stimulates the generation of leukotriene ( LTC4 ) and 15-hydroxyeicosatetraenoic acid, but not of thromboxanes and prostaglandins.”
Leukotrienes in mucosal damage and protection.“A number of sulfhydryl-containing or sulfhydryl-blocking agents as well as metals protected against mucosal damage and simultaneously prevented the stimulation of leukotriene C4 formation induced by ethanol.”
“Intragastric ethanol stimulates mucosal formation of leukotriene C4 in the rat stomach.”
“3 Oral instillation of ethanol caused gastric mucosal damage and simultaneously induced a selective increase in the ex vivo release of LTC4 from rat gastric mucosa, while release of cyclo‐oxygenase products of arachidonate metabolism was not significantly affected.”
“reduced the mucosal damaging effect of ethanol and simultaneously inhibited LTC4 release.”
“2 Oral administration of ethanol to rats in vivo, induced macroscopic damage to the gastric mucosa and markedly increased the formation of the 5‐lipoxygenase products, LTB4 and LTC4 , from the mucosa ex vivo.”
“Challenge of the rat gastric mucosa in vitro with ethanol induced a concentration-dependent increase in the formation of LTB4 and LTC4 , but not 6-keto PGF1 alpha.”
“Challenge with absolute ethanol likewise enhanced the mucosal formation of LTC4 whereas the mucosal formation of 6-keto-PGF1 alpha was unaffected.”
“ Ethanol administration resulted in a fourfold increase in LTC4 synthesis.”
“It was found that intragastric instillation of ethanol increases gastric mucosal release of LTC4 in a dose- and time-dependent manner parallel to the production of gastric lesions.”
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