Possible Interaction: Ethanol and Leukotriene B4

“Moreover, ethanol enhanced expression and nuclear localization of 5-Lox and stimulated LTB4 biosynthesis in human tongue SCC cells (SCC-15 and SCC-4) in vitro.”

“Furthermore, acute gastric damage produced by ethanol is accompanied by marked increases in the mucosal formation of LTC4 and LTB4.”

“However, the total LTB4 production (LTB4 plus omega-oxidized metabolites) was significantly decreased in the samples treated with ethanol.”

“Using the calcium ionophore A23187 as stimulus, the leukotriene B4 (LTB4) and leukotriene C4 (LTC4) generation were dose-dependently impaired by ethanol.”

“Catabolic processes inactivate LTB4, however, low levels of ethanol (2-10mM) interfere with normal B-oxidation of LTB4 ~ o.2oby hepatocytes resulting in the accumulation of a novel =~ metabolite, 3(S)-hydroxy-LTB 4 [3(S)-OH-LTB4] [1, 2].”

“From these …: (1) leukotriene B4 , at a dose of 2 … colonic ulceration induced by 30% ethanol ; (2) this action of leukotriene B4 is not shared by the same dose of the other inflammatory … neutrophils are the major source of colonic leukotriene B4 synthesis in a rat model of colitis.”

“In the corn oil group, ethanol feeding was associated with a significant increase in liver LTB4.”

“ Ethanol in low concentrations significantly alters the hepatocyte metabolism of the neutrophil chemotactic lipid leukotriene B4 (LTB4).”

“These results suggest that the presence of ethanol can substantially alter inactivation of LTB4 by the liver and may mediate neutrophil accumulation into the liver, thereby contributing to the pathogenesis of alcoholic hepatitis even when LTB4 biosynthesis occurs at some site distant to the liver.”

“The metabolic degradation and inactivation of cysteinyl leukotrienes in vivo and of LTB4 in isolated hepatocytes was potently inhibited by ethanol.”

“2 Oral administration of ethanol to rats in vivo, induced macroscopic damage to the gastric mucosa and markedly increased the formation of the 5‐lipoxygenase products, LTB4 and LTC4, from the mucosa ex vivo.”

“Challenge of the rat gastric mucosa in vitro with ethanol induced a concentration-dependent increase in the formation of LTB4 and LTC4, but not 6-keto PGF1 alpha.”

“Exposure of the rat gastric mucosa to ethanol in-vivo, produced a concentration-related increase in the mucosal formation of leukotriene B4 (LTB4) which was correlated with macroscopically-apparent haemorrhagic damage to the mucosa.”