Possible Interaction: Ethanol and Leucine

“Participants who were homozygous or heterozygous for the 7 (or longer) repeat allele were classified as DRD4 L, whereas the other participants were classified as DRD4 S. Results suggested that DRD4 L participants demonstrated significantly higher craving after consumption of alcohol as compared with the control beverage.”

“Starting at 2 hours, the ethanol group had a statistically significant relative fluid deficit averaging .5 L by 3 hours.”

“Calpain activities, cathepsin L levels and cytochrome c release rates were significantly increased in alcohol group compared to control group (p < 0.05).”

“Moreover, [14C] leucine incorporation into mitochondrial membranes was depressed by 21% after ethanol treatment.”

“Prior chronic ethanol consumption depressed (p less than 0.05) placental uptake of AIB (38%), cycloleucine (45%), Ala (35%), Leu (25%), and Lys (34%).”

“After 15 days of ethanol feeding, leucine incorporation into total hepatocyte protein, as well as into total intracellular (subcellular fractions) or extracellular (secreted) proteins was substantially inhibited.”

“Abstract Incorporation in vitro of labeled leucine into isolated rat liver mitochondria was decreased in animals chronically fed ethanol.”

“At both ethanol concentrations, in comparison to trileucine, l-leucine significantly reduced the primary particle size and span and increased the fraction of submicrometer particles of the Survanta EEG powders.”

“The dynamic analysis … concentrations showed that ETOH … L clearance (0.0016 +/- 0.0011 vs. 0.0029 +/- 0.0002 min(-1); P = 0.0156), whereas no difference was observed for … conversion of the rate of G disappearance to L (0.0033 +/- 0.0012 vs. 0.0031 +/- 0.0005 min(-1)).”

“Furthermore, the ethanol treatment reduced the whole‐cell pulse‐labeling of RNA with (5–3H) orotic acid and protein with (14C) leucine in the postmitochondrial supernatant.”