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Last Updated: 3 years ago

Possible Interaction: Ethanol and Leptin





Research Papers that Mention the Interaction

A direct inhibitory effect of alcohol on the adipocytes is possible, but increased disposal of leptin via hepatic metabolism or renal excretion could also contribute.
Alcohol and alcoholism  •  2004  |  View Paper
These results indicate that moderate alcohol consumption (15-30 g of alcohol per day ) increases serum leptin levels in postmenopausal women and may predispose moderate drinkers to the morbidities associated with chronic elevations of this hormone including cancer.
Journal of the National Cancer Institute  •  2003  |  View Paper
Results showed that ethanol increased plasma and hepatic triglyceride and cholesterol content, and affected plasma levels of insulin, adiponectin, leptin , and ghrelin.
Journal of food science  •  2017  |  View Paper
Similarly, leptin administration to ethanol (6.32 g kg(-1) body weight) fed mice for 45 days significantly lowered the concentration of these cytokines in the circulation; however, leptin alone (230 microg kg(-1) body weight i.p.
Cytokine  •  2007  |  View Paper
Our results suggest that leptin at a concentration of 31.2 nM prevents ethanol elicited cytotoxicity as evidenced by MTT and trypan blue dye exclusion assay.
leptin treatment … with ethanol showed protection against ethanol mediated cellular damage as indicated by significantly decreased levels of reactive oxygen species (ROS) and thiobarbituric acid reactive substances (…) and significantly increased levels of reactive nitrogen species (RNS), reduced glutathione (GSH) and elevated activities of superoxide dismutase (SOD) and catalase (CAT).
Biochimica et biophysica acta  •  2007  |  View Paper
These findings suggest that ethanol time‐ and dose‐dependently inhibits the leptin action, in part via p38 MAPK.
FEBS letters  •  2002  |  View Paper
Moreover, leptin also plays an important role in mediating the response to different oral aggressors, such as periodontopathic bacteria and alcohol , as well as its involvement in certain types of mouth cancer.
Investigacion clinica  •  2015  |  View Paper
The ghrelin and leptin levels fell after ingestion of alcohol , whereas the obestatin and GLP-1 levels remained unchanged.
Endocrine research  •  2012  |  View Paper
Recent evidence suggests that leptin is associated with increased craving for alcohol and with shorter length of abstinence during alcohol treatment.
Pharmacology Biochemistry and Behavior  •  2011  |  View Paper
Chronic use of alcohol can be affected by the altered level of ghrelin and leptin which regulate food-seeking behavior having similar mechanism of controlling alcohol-craving behavior.
Alcoholism, clinical and experimental research  •  2011  |  View Paper
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