Possible Interaction: Ethanol and Leptin

“A direct inhibitory effect of alcohol on the adipocytes is possible, but increased disposal of leptin via hepatic metabolism or renal excretion could also contribute.”

“These results indicate that moderate alcohol consumption (15-30 g of alcohol per day ) increases serum leptin levels in postmenopausal women and may predispose moderate drinkers to the morbidities associated with chronic elevations of this hormone including cancer.”

“Results showed that ethanol increased plasma and hepatic triglyceride and cholesterol content, and affected plasma levels of insulin, adiponectin, leptin , and ghrelin.”

“Similarly, leptin administration to ethanol (6.32 g kg(-1) body weight) fed mice for 45 days significantly lowered the concentration of these cytokines in the circulation; however, leptin alone (230 microg kg(-1) body weight i.p.”

“Our results suggest that leptin at a concentration of 31.2 nM prevents ethanol elicited cytotoxicity as evidenced by MTT and trypan blue dye exclusion assay.”

“… leptin treatment … with ethanol showed protection against ethanol mediated cellular damage as indicated by significantly decreased levels of reactive oxygen species (ROS) and thiobarbituric acid reactive substances (…) and significantly increased levels of reactive nitrogen species (RNS), reduced glutathione (GSH) and elevated activities of superoxide dismutase (SOD) and catalase (CAT).”

“These findings suggest that ethanol time‐ and dose‐dependently inhibits the leptin action, in part via p38 MAPK.”

“Moreover, leptin also plays an important role in mediating the response to different oral aggressors, such as periodontopathic bacteria and alcohol , as well as its involvement in certain types of mouth cancer.”

“The ghrelin and leptin levels fell after ingestion of alcohol , whereas the obestatin and GLP-1 levels remained unchanged.”

“Recent evidence suggests that leptin is associated with increased craving for alcohol and with shorter length of abstinence during alcohol treatment.”

“Chronic use of alcohol can be affected by the altered level of ghrelin and leptin which regulate food-seeking behavior having similar mechanism of controlling alcohol-craving behavior.”