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Last Updated: 3 years ago

Possible Interaction: Ethanol and Lauric Acid

supplement:

Ethanol

supplement:

Lauric Acid

Research Papers that Mention the Interaction

The (omega-1)-hydroxylation of lauric acid was inhibited by ethanol (Ki = 3.5 mM), acetone (IC50 = 10 mM) dimethylsulfoxide, chlorzoxazone (competitive inhibitors of CYP2E1), diethyldithiocarbamate, and diallylsulfide (both selective mechanism-based inactivators of CYP2E1).
Biochemical pharmacology  •  1995  |  View Paper
For meconium of the ethanol offspring (n=25 fetuses) compared with the sucrose offspring (n=23 fetuses), the total FAEE concentration was 8-fold higher; and lauric , palmitic, stearic and oleic AEE concentrations were at least 5-fold higher for the ethanol group.
Therapeutic drug monitoring  •  2006  |  View Paper
Ethanol increased the microsomal lauric acid omega-hydroxylation and the aminopyrine N-demethylation catalyzed by cytochrome P450.
General pharmacology  •  1998  |  View Paper
It was considered that lauric acid exerts an effect on both the polar and nonpolar regions of lipids of the stratum corneum, and the cooperative interaction of ethanol and lauric acid increases the participation of the polar pathway of drugs.
Biological & pharmaceutical bulletin  •  1994  |  View Paper
Adaptation to ethanol led to a decrease in the unsaturated/saturated ratio, mainly resulting from an increase in the contribution of short‐length fatty acid C12:0 and a decrease of C18:1.
Letters in applied microbiology  •  2015  |  View Paper