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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Ethanol
drug:
Kynurenic Acid
Research Papers that Mention the Interaction
“Thus, the potential interaction between KYNA and alcohol occurring in human body after ingestion of alcoholic beverages was proven.”
Presence of kynurenic acid in alcoholic beverages - Is this good news, or bad news?“Furthermore, the gene expression profile from alcohol and KYNA co-administration was significantly different from that of alcohol or KYNA administration alone.”
“Strikingly, Indolamine 2,3-dioxygenase 1, a rate-limiting enzyme in tryptophan metabolism, was significantly increased in the brain after a combined exposure of alcohol and KYNA , suggesting that Trp metabolism was skewed towards the kynurenine pathway in the brain.”
Organ-differential responses to ethanol and kynurenic acid, a component of alcoholic beverages in gene transcription.“These results point to a critical involvement of the reward circuitry in the reduction of EtOH consumption induced by KYN and KYNA increments.”
“We now show that kynurenic acid significantly blocks restraint-cold stress ulcers, ethanol ulcers and basal, non-stimulated gastric acid secretion in normal rats not subjected to neurotoxin challenge.”
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