Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Ethanol and Kynurenic Acid

supplement:

Ethanol

Research Papers that Mention the Interaction

Thus, the potential interaction between KYNA and alcohol occurring in human body after ingestion of alcoholic beverages was proven.
Medical hypotheses  •  2019  |  View Paper
Furthermore, the gene expression profile from alcohol and KYNA co-administration was significantly different from that of alcohol or KYNA administration alone.
Strikingly, Indolamine 2,3-dioxygenase 1, a rate-limiting enzyme in tryptophan metabolism, was significantly increased in the brain after a combined exposure of alcohol and KYNA , suggesting that Trp metabolism was skewed towards the kynurenine pathway in the brain.
Gene  •  2020  |  View Paper
These results point to a critical involvement of the reward circuitry in the reduction of EtOH consumption induced by KYN and KYNA increments.
Neuropharmacology  •  2018  |  View Paper
We now show that kynurenic acid significantly blocks restraint-cold stress ulcers, ethanol ulcers and basal, non-stimulated gastric acid secretion in normal rats not subjected to neurotoxin challenge.
Research communications in chemical pathology and pharmacology  •  1989  |  View Paper