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Last Updated: 3 years ago

Possible Interaction: Ethanol and Kynurenic Acid



Research Papers that Mention the Interaction

Thus, the potential interaction between KYNA and alcohol occurring in human body after ingestion of alcoholic beverages was proven.
Medical hypotheses  •  2019  |  View Paper
Furthermore, the gene expression profile from alcohol and KYNA co-administration was significantly different from that of alcohol or KYNA administration alone.
Strikingly, Indolamine 2,3-dioxygenase 1, a rate-limiting enzyme in tryptophan metabolism, was significantly increased in the brain after a combined exposure of alcohol and KYNA , suggesting that Trp metabolism was skewed towards the kynurenine pathway in the brain.
Gene  •  2020  |  View Paper
These results point to a critical involvement of the reward circuitry in the reduction of EtOH consumption induced by KYN and KYNA increments.
Neuropharmacology  •  2018  |  View Paper
We now show that kynurenic acid significantly blocks restraint-cold stress ulcers, ethanol ulcers and basal, non-stimulated gastric acid secretion in normal rats not subjected to neurotoxin challenge.
Research communications in chemical pathology and pharmacology  •  1989  |  View Paper