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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Ketoconazole
Research Papers that Mention the Interaction
“ Alcohol and hepatotoxic agents (for example, paracetamol, amoxicillin, ketoconazole ) should be avoided.”
[What General/Family Medicine Practitioner should Know about Viral Hepatitis].“Production of alcohol derivatives was significantly inhibited by anti-CYP3A antibodies and by ketoconazole.”
“ Ketoconazole also dose dependently attenuated ethanol induced increase in myeloperoxidase activity and protected gastric mucosa against ethanol-induced depletion of non-protein sulfhydryl.”
Protective effect of ketoconazole against experimentally induced gastric ulcers in rats.“The mean residence time decreased from 0.60 +/- 0.15 (control) to 0.43 +/- 0.10 hr with ketoconazole (P less than .05) after 5 mg/kg of MPL ( free alcohol).”
“The increase of P-gp and CYP3A4 expression by the IO and CP ethanol extracts was inhibited by ketoconazole , an inhibitor of PXR activation.”
Extracts of Immature Orange (Aurantii fructus immaturus) and Citrus Unshiu Peel (Citri unshiu pericarpium) Induce P-Glycoprotein and Cytochrome P450 3A4 Expression via Upregulation of Pregnane X Receptor
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