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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Ivermectin
Research Papers that Mention the Interaction
“Furthermore, IVM was shown to reduce ethanol consumption via P2X4R potentiation in vivo, supporting the involvement of P2X4Rs in IVM’s anti-alcohol effects and that P2X4Rs can be used as a platform for developing novel anti-alcohol compounds.”
“Investigations using recombinant cell models and animal models of alcohol drinking have reported that IVM , ABM, and MOX, but not SEL, were able to antagonize the inhibitory effects of ethanol on P2X4Rs in vitro and reduce ethanol intake in vivo.”
Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders“However, at 2h after ivermectin administration, patients given alcohol had significantly lower plasma ivermectin levels than fed patients or fasting patients.”
“Previously, we reported that avermectin compounds Ivermectin [IVM] and moxidectin [MOX]) significantly reduced ethanol intake in male and female mice.”
“Furthermore, IVM reduced ethanol consumption in male and female rodents, whereas male P2X4R KO mice were less sensitive to the anti-alcohol effects of IVM, compared to wildtype (WT) mice, further supporting a role for P2X4Rs as targets of IVM's action.”
Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice.“Using a translational approach, our laboratory reported that ivermectin , an FDA‐approved, human and animal anti‐parasitic agent, can significantly reduce ethanol intake in male and female mice across different drinking paradigms.”
“The IVM group drank significantly less ethanol over the 30-day period compared to the placebo (blank strip) and the no-treatment groups.”
“Earlier work found that IVM significantly reduced ethanol intake in mice and that this effect likely reflects IVM's ability to modulate ligand-gated ion channels.”
“ IVM and ABM significantly reduced ethanol intake and antagonized the inhibitory effects of ethanol on P2X4R function.”
“ IVM significantly reduced ethanol intake in P2X4R KO and WT mice, but the degree of reduction was 50 % less in the P2X4R KO mice.”
“ Ivermectin (IVM), an FDA approved anthelmintic agent, can significantly reduce ethanol intake in mice following acute administration.”
“Furthermore, IVM reduced ethanol intake in mice.”
“We recently reported that ivermectin (IVM), an antiparasitic used in animals and humans, antagonized ethanol inhibition of P2X4Rs.”
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