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Last Updated: 3 years ago

Possible Interaction: Ethanol and Ivermectin



Research Papers that Mention the Interaction

Furthermore, IVM was shown to reduce ethanol consumption via P2X4R potentiation in vivo, supporting the involvement of P2X4Rs in IVM’s anti-alcohol effects and that P2X4Rs can be used as a platform for developing novel anti-alcohol compounds.
Investigations using recombinant cell models and animal models of alcohol drinking have reported that IVM , ABM, and MOX, but not SEL, were able to antagonize the inhibitory effects of ethanol on P2X4Rs in vitro and reduce ethanol intake in vivo.
Psychopharmacology  •  2018  |  View Paper
However, at 2h after ivermectin administration, patients given alcohol had significantly lower plasma ivermectin levels than fed patients or fasting patients.
Acta tropica  •  2013  |  View Paper
Previously, we reported that avermectin compounds Ivermectin [IVM] and moxidectin [MOX]) significantly reduced ethanol intake in male and female mice.
Alcohol  •  2020  |  View Paper
Furthermore, IVM reduced ethanol consumption in male and female rodents, whereas male P2X4R KO mice were less sensitive to the anti-alcohol effects of IVM, compared to wildtype (WT) mice, further supporting a role for P2X4Rs as targets of IVM's action.
Alcohol  •  2018  |  View Paper
Using a translational approach, our laboratory reported that ivermectin , an FDA‐approved, human and animal anti‐parasitic agent, can significantly reduce ethanol intake in male and female mice across different drinking paradigms.
Neuropharmacology  •  2017  |  View Paper
The IVM group drank significantly less ethanol over the 30-day period compared to the placebo (blank strip) and the no-treatment groups.
Alcohol  •  2015  |  View Paper
Earlier work found that IVM significantly reduced ethanol intake in mice and that this effect likely reflects IVM's ability to modulate ligand-gated ion channels.
IVM and ABM significantly reduced ethanol intake and antagonized the inhibitory effects of ethanol on P2X4R function.
The international journal of neuropsychopharmacology  •  2014  |  View Paper
IVM significantly reduced ethanol intake in P2X4R KO and WT mice, but the degree of reduction was 50 % less in the P2X4R KO mice.
Neurochemical Research  •  2014  |  View Paper
Ivermectin (IVM), an FDA approved anthelmintic agent, can significantly reduce ethanol intake in mice following acute administration.
Neuroreport  •  2014  |  View Paper
Furthermore, IVM reduced ethanol intake in mice.
We recently reported that ivermectin (IVM), an antiparasitic used in animals and humans, antagonized ethanol inhibition of P2X4Rs.
Purinergic Signalling  •  2013  |  View Paper
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