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Last Updated: a year ago

Possible Interaction: Ethanol and Isradipine

supplement:

Ethanol

Research Papers that Mention the Interaction

Breath-alcohol levels were significantly lower after isradipine pretreatment, which suggests isradipine altered the bioavailability of ethanol.
Alcoholism, clinical and experimental research  •  1998  |  View Paper
ethanol treatment in … antagonist, isradipine , was included in the perfusion medium at 4 μM. Another dihydropyridine, felodipine, which had no activity against withdrawal signs in vivo, did … hyperexcitability in vivo, had no effect on the withdrawal changes in field potentials at 30 μM; higher concentrations affected the control slices.
British journal of pharmacology  •  1998  |  View Paper
Here, we asked whether ISR&NTX would lose its ability to reduce the reinforcing effects of cocaine and alcohol when given daily.
Pharmacology Biochemistry and Behavior  •  1998  |  View Paper
Chronic administration of the calcium channel antagonist, isradipine (PN-200-110) during ethanol treatment significantly decreased the withdrawal syndrome, both in vivo and in vitro.
Alcohol and alcoholism  •  1996  |  View Paper
While nifedipine, darodipine, and verapamil (each at the dose of 20 mg/kg thrice daily) produced a modest reduction in ethanol intake, isradipine (at the dose of 1 mg/kg three times a day) reduced ethanol intake by over 70%.
Alcoholism, clinical and experimental research  •  1992  |  View Paper
2 The (+)‐isomer of the calcium channel antagonist PN 200–110 isradipine ) significantly decreased all the recorded signs of hyperexcitability in the slices during ethanol withdrawal.
British journal of pharmacology  •  1991  |  View Paper
Tonic dopamine release in the nucleus accumbens also was higher after intra-VTA infusion of isradipine , even when factoring in the decreased tonic dopamine release induced by isradipine’s ethanol vehicle.
Neuropsychopharmacology  •  2018  |  View Paper
Nicardipine and isradipine , but not diltiazem, simultaneously increased water intake and attenuated preference for ethanol.
Behavioural pharmacology  •  1994  |  View Paper