Possible Interaction: Ethanol and Isradipine

“Breath-alcohol levels were significantly lower after isradipine pretreatment, which suggests isradipine altered the bioavailability of ethanol.”

“… ethanol treatment in … antagonist, isradipine , was included in the perfusion medium at 4 μM. Another dihydropyridine, felodipine, which had no activity against withdrawal signs in vivo, did … hyperexcitability in vivo, had no effect on the withdrawal changes in field potentials at 30 μM; higher concentrations affected the control slices.”

“Here, we asked whether ISR&NTX would lose its ability to reduce the reinforcing effects of cocaine and alcohol when given daily.”

“Chronic administration of the calcium channel antagonist, isradipine (PN-200-110) during ethanol treatment significantly decreased the withdrawal syndrome, both in vivo and in vitro.”

“While nifedipine, darodipine, and verapamil (each at the dose of 20 mg/kg thrice daily) produced a modest reduction in ethanol intake, isradipine (at the dose of 1 mg/kg three times a day) reduced ethanol intake by over 70%.”

“2 The (+)‐isomer of the calcium channel antagonist PN 200–110 isradipine ) significantly decreased all the recorded signs of hyperexcitability in the slices during ethanol withdrawal.”

“Tonic dopamine release in the nucleus accumbens also was higher after intra-VTA infusion of isradipine , even when factoring in the decreased tonic dopamine release induced by isradipine’s ethanol vehicle.”

“Nicardipine and isradipine , but not diltiazem, simultaneously increased water intake and attenuated preference for ethanol.”