Possible Interaction: Ethanol and Isoproterenol

“Although treatment with ethanol alone did not affect t-PA gene transcription or mRNA expression, it augmented isoproterenol (ISO)-stimulated t-PA gene transcription and mRNA levels by 3.4- and 2.8-fold, respectively, and decreased plasminogen activator inhibitor-1 mRNA levels by 65%.”

“In contrast, the ethanol ratio decreased markedly with isoproterenol.”

“ Isoprenaline caused a rapid and concentration-dependent decrease in the ethanol clearance ratio (index of local blood flow, i.e. a decrease in ethanol ratio implies an increase in blood flow).”

“Stimulation of local blood flow and lipolysis with the beta-adrenoceptor agonist isoprenaline caused an increase in ethanol escape (P = 0.01) and a 100% rise in the dialysate glycerol level (P = 0.001).”

“RESULTS The 1.25% (V/V) et anol si gnificantly augmented the corporal relaxation induced by iso prenaline (1 0(-9) - 10(-5) mol/L).”

“Baseline CBF was not affected in any group; however, isoproterenol stimulation of CBF was blunted by alcohol exposure and actually slowed below baseline in the smoke plus alcohol group.”

“Similarly, isoproterenol stimulated a 2- to 3-fold increase in PKA activity in control rats, but this PKA response to isoproterenol was blunted in rats fed increasing concentrations of ethanol.”

“Compared with controls, the alcohol atria demonstrated a significant depression in the inotropic effect of the beta-adrenergic agonist isoproterenol over a broad concentration range (10(-9)-10(-6) M).”

“In conclusion, ethanol consumption in both young and aged rats was associated with markedly improved arterial relaxations to isoproterenol and cromakalim, as well as clearly augmented relaxation to acetylcholine during inhibition of cyclooxygenase and nitric oxide synthase.”

“We previously found that beta adrenergic agonists such as norepinephrine and isoproterenol potentiate the depressant actions of ethanol (EtOH) on cerebellar Purkinje neurons.”