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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Administration of INH , 10 mg/kg might cause some extra risks for driving in the very beginning of the treatment and in combination with alcohol.”
“In simulated driving, INH antagonized the deleterious effect of alcohol on attention.”
Effects of isoniazid on psychomotor skills related to driving.“The following factors were associated with an increased risk of severe liver dysfunction: hepatobiliary abnormalities, consumption of alcohol 5 times or more per week before commencing INH , and abnormal high values of ALP before commencing INH. [”
“In the beginning of treatment and in combination with alcohol , a dose of 10 mg/kg of isoniazid might cause some extra risks in driving, according to M. Linnoila and M. J. Mattila in /. Clin.”
“Blood acetaldehyde levels were also evaluated after co-administration of ETH with DIS or ISO.”
“The possibility that the ETH intolerance observed in ISO treatment is a central synergistic effect cannot be excluded.”
The Alcohol Intolerance Produced by Isoniazid Is Not Due to a Disulfiram-Like Reaction Despite Aldehyde Dehydrogenase Inhibition“… isoniazid (INH) in … rats with ethanol these parameters were changed in that central-central bridging fibrosis was increased, as was lipid peroxidation, whereas INH reduced the ethanol-induced …, the increase in total P450 and CYP2EI, as well as the NADPH oxidation rate and the elevation of serum transaminase levels.”
“The generation of 1-hydroxybutyl radicals by EtOH microsomes was inhibited by 40, 48 and 68%, respectively, by the addition of isoniazid , tryptamine and octylamine, compounds known to specifically affect the NADPH oxidase activity of this isoenzyme.”
“Both activities were increased by ethanol but decreased by isoniazide , an agent which induces the same form of cytochromes P-450 as ethanol.”
“Moreover, ethanol , like diazepam, reduced the increase of [35S]TBPS binding elicited by isoniazid (350 mg/kg, s.c.),”
“Microsomal oxidation of ETOH and aniline p-hydroxylation (expressed per nmol cytochrome P-450) were enhanced dramatically by ETOH and INH , whereas PB and BF had no effect on these enzymatic activities.”
“When combinations of isoniazid (2 ± 10-3M) and ethanol (0.1M), isoniazid and chloramphenicol (10-3M) or ethanol and chloramphenicol were present in the same incubation, their inhibitory effects on heme and protein synthesis were additive.”
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