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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Isoflurane
Research Papers that Mention the Interaction
“Thus, acute combinations of ethanol and isoflurane are more effective than either alone but less than the expected sum.”
“Twenty, 39, and 79 percent of this ethanol anesthetic dose reduced isoflurane ED50 by 0, 8, and 70 percent, respectively.”
Effects of Acute and Chronic Ethanol Administration on Isoflurane Requirement in Mice“These data indicate that ethanol mimics the effects of isoflurane presumably through a cellular preconditioning mechanism that involves dehydration-induced protein aggregation.”
“Levels of DNA damage in lymphocytes, bone marrow, and the organ tissues of rats exposed to isoflurane were found to increase time dependently, and alcohol increased DNA damage.”
“Both ethanol and sodium acetate reduced anesthetic requirement for isoflurane and sevoflurane in a dose-dependent fashion.”
Role of adenosine in the ethanol-induced potentiation of the effects of general anesthetics in rats.“… ethanol … isoflurane , ALA-S activity was increased (control values: 0.071 +/- 0.022 nmol/mg, n = 10; treated animals: 0.110 +/- 0.034 nmol/mg, n = ….242 +/- 0.075 nmol/mg; treated animals, n = 6: PBGase: 0.063 +/- 0.013 nmol/mg; deaminase: 0.145 +/- 0.045 nmol/mg).”
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