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Possible Interaction: Ethanol and Iron, Dietary

supplement:

Ethanol

supplement:

Iron, Dietary

Research Papers that Mention the Interaction

Ethanol consumption and/or liver damage may alter liver content of several trace elements, as iron , zinc, copper, and manganese.
Alcohol  •  1997  |  View Paper
Our findings therefore suggest that iron could CPY2E1-independently enhance the oxidative stress induced by alcohol , which probably contributes to the pathogenesis of alcoholic liver disease.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2012  |  View Paper
Specifically, the interactions between alcohol and secondary risk factors (high-fat diet, iron , tobacco, medications, female gender) and comorbidities (viral hepatitis, diabetes) are of urgent epidemiological importance.
Journal of Gastroenterology  •  2007  |  View Paper
Understanding these molecular mechanisms is of considerable clinical importance because both alcoholic liver disease and genetic hemochromatosis are common diseases, in which alcohol and iron appear to act synergistically to cause liver injury.
World journal of gastroenterology  •  2007  |  View Paper
stress as well as iron accumulation.6 The combined prooxidant potentials of ethanol and iron are at least additive and possibly synergistic with regard to induction of oxidative stress and antioxidant depletion in hepatocytes.
Journal of Gastroenterology  •  2006  |  View Paper
The hemochromatosis (HFE) protein is involved in iron metabolism and the synergistic effect between iron and alcohol is suggested in the progression of alcoholic cirrhosis (2).
Clinical genetics  •  2006  |  View Paper
In addition, the cumulative effects of other forms of liver injury may result when iron and alcohol are present concurrently.
The most likely explanation would seem to be the added co-factor effect of iron and alcohol , both of which cause oxidative stress, hepatic stellate cell activation, and hepatic fibrogenesis.
Alcohol  •  2003  |  View Paper
The fibrogenic potential of iron is even more dramatic when iron acts in concert with other hepatotoxins such as alcohol.
Alcohol  •  2003  |  View Paper
It is known that the regular consumption of alcohol is responsible for the disruption of normal iron metabolism in humans, resulting in the excess deposition of iron in the liver in approximately one-third of alcoholic subjects.
Journal of gastroenterology and hepatology  •  1999  |  View Paper
Experiments were carried out to attempt to link CYP2E1, iron, and oxidative stress as a potential mechanism by which iron increases ethanol toxicity.
Iron can potentiate the toxicity of ethanol.
Molecular pharmacology  •  1998  |  View Paper
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