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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Ethanol and Irinotecan



Research Papers that Mention the Interaction

Furthermore, the AUC0-24 h of irinotecan and SN38 were significantly reduced but their clearance was significantly increased in the disrupted EHC of BA by 50% ethanol intake.
Most importantly, chronic ethanol consumption had a significant impact on the pharmacokinetics (AUC0-24 h and clearance) of irinotecan and SN38; hence colon cancer patients with chronic alcohol consumption treated with irinotecan deserve our close attention.
Alcohol and alcoholism  •  2020  |  View Paper
Indeed, there are numerous commonly prescribed drugs with significant carboxylesterase-mediated metabolism such as enalapril, lovastatin, irinotecan , clopidogrel, prasugrel, methylphenidate, meperidine, and oseltamivir that may interact with ethanol.
Drug Metabolism and Disposition  •  2010  |  View Paper