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Last Updated: 2 years ago

Possible Interaction: Ethanol and Interleukin-10



Research Papers that Mention the Interaction

In contrast, the induction of IL-10 by LPS is enhanced by ethanol treatment, suggesting that elevated IL-10 may play a role in ethanol-induced suppression of IL-12.
Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence  •  2011  |  View Paper
IL-10 increased ethanol induced apoptosis in primary culture rat hepatocytes (28%).
Life sciences  •  2005  |  View Paper
Acute alcohol inhibited TLR8- or TLR4-induced TNF alpha protein and mRNA induction while it augmented IL-10 production in monocytes.
BMC Immunology  •  2011  |  View Paper
The mechanisms of IL‐10 induction by alcohol remain poorly understood.
Using specific Src (PP2), JNK1/2 (… p38 (SB203580) inhibitors, we determined that alcohol treatment alone induced and together with LPS, augmented the DNA‐binding capacity of … protein‐1 (Sp‐1) and AP‐1 transcription factors involved in IL‐10 production via Src‐mediated activation … p38 MAPK and JNK, respectively.
Journal of leukocyte biology  •  2007  |  View Paper
Reduced allostimulatory capacity of DCs treated with alcohol in vitro correlated with decreased co-stimulatory molecule (B7.1 and B7.2) expression, as well as with reduced interleukin (IL)-12 and increased IL-10 concentrations, in mixed lymphocyte cultures.
Alcohol  •  2004  |  View Paper
Experiments with anti-IL-10 neutralizing antibody show that ethanol may prevent monocyte IL-12 induction via IL-10.
Alcoholism, clinical and experimental research  •  1998  |  View Paper
Furthermore, ethanol significantly augmented LPS-induced monocyte IL-10 secretion at 18 h. Data also show that ethanol-induced changes in monocyte IL-10 mRNA levels mirror those seen at the protein levels.
Here, we tested the hypothesis that some of the regulatory effects of ethanol on monocyte functions are mediated by elevated M phi IL-10 production.
Physiologically relevant in vitro doses of ethanol (25-100 mM) resulted in significantly increased IL-10 secretion by normal blood monocytes after 18 h stimulation.
Cytokine  •  1996  |  View Paper
In contrast, acute ethanol treatment induces monocyte production of mediators with immunoinhibitory potential, including transforming growth factor-beta and IL-10.
We further show that ethanol not only induces monocyte/macrophage (Mø) IL-10 and transforming growth factor-beta, but even augments bacterial (both LPS and SEB) stimulation-induced production of both of these cytokines.
Alcoholism, clinical and experimental research  •  1996  |  View Paper
Ethanol consumption decreased plasma levels of IL-10 in WT mice.
These findings provided novel evidence that IL-10 counteracted the initial mechanisms whereby ethanol induces its cardiorenal damages.
We hypothesized that IL-10 would limit the deleterious effects induced by ethanol consumption in the cardiorenal system.
Life sciences  •  2020  |  View Paper
Immunohistochemistry analyses determined that ethanol decreased IL-10 by 50 % in the basolateral amygdala (BLA) but had no effect on IL-4.
Journal of Neuroimmune Pharmacology  •  2016  |  View Paper
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