Possible Interaction: Ethanol and Interferon Gamma-1B

“Two different effects of … reported: (a) ethanol … IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing … into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells.”

“Here, we found … in vitro acute ethanol treatment (25-100 mM) results in a dose-… and significant increase of IL-12 in IFN-gamma (100 U/ml) plus Staphylococcal enterotoxin B (SEB; 1 microg/ml) stimulated monocytes … mononuclear cells but not in unstimulated cells from non-alcoholic blood donors.”

“Moreover, acute ethanol treatment augmented IL-12 production in IFN-gamma-treated monocytes in response to SEB stimulation (25 mM ethanol, p < 0.01; 100 mM ethanol, p < 0.01).”

“ Ethanol extract of Glycyrrhizae Radix, black beans, Angelicae Radix, and Cnidii Rhizoma (0.3-15 mg/ml) in both regimens significantly inhibited IFN-gamma and TNF-alpha-mediated cytotoxicity of rat thyroid cells (p<0.05, p<0.01).”

“The results revealed that expression of IL-2 and IFN-gamma mRNA were dose-dependently enhanced by the ethanol extract of ginseng.”

“ Ethanol significantly reduced both basal and beta-EP-induced levels of granzyme B and IFN-gamma.”

“ Ethanol also significantly reduced the protein levels of perforin and IFN-gamma and the enzyme activity of granzyme B in alcohol-fed animals as compared with pair-fed animals.”

“Our data support the contention that ethanol , by up-regulating phosphotyrosine phosphatase, diminishes the IFN-gamma signal transduction pathway.”