Possible Interaction: Ethanol and Interferon-Alpha

“Our study demonstrates that alcohol enhances IFN-α production by CD11b+Ly6G+ cells in the lungs of young Mtb-infected mice, which leads to macrophage necroptosis and increased mortality.”

“Here, we explored a possibility that ethanol metabolism potentiates HCV-mediated dysregulation of IFN-α signaling in liver cells via impairment of methylation reactions.”

“Increased concentrations of IFN-γ were detected in 24-hour blood samples of alcohol treated mice.”

“ Alcohol could compromise the anti‐hepatitis C virus (HCV) function of interferon‐alpha (IFN‐α).”

“ Alcohol suppressed intracellular expression of type I interferons ( IFN-α/β ) in human hepatocytes.”

“In addition, alcohol induced the expression of suppressors of cytokine signaling (SOCS-2 and SOCS-3), the key negative regulators of IFN-α/β expression.”

“In contrast, when combined with exogenously applied IFN-α, ethanol inhibited the antiviral actions of IFN against HCV replication, involving inhibition of IFN-induced Stat1 tyrosine phosphorylation.”

“We previously showed that IFNγ signal transduction was suppressed by ethanol in recombinant HepG2 cells (VL‐17A cells), which express alcohol dehydrogenase (ADH) and CYP2E1.”

“Likewise, ethanol (100 mM) in vitro reduced MCP-1 levels in response to SEB, PHA, or IFNγ stimulation in mononuclear cells (31–62% reduction).”

“We can wonder, despite of the poor recruitment, about the potential involvement of driving under the influence of alcohol , antecedents of MDE induced-discontinuation of a last treatment by interferon alpha or antecedents of suicide attempt, in the appearance of MDE under interferon alpha.”

“ Alcohol also compromised the anti‐HCV effect of IFN‐α.”

“In conclusion, alcohol , probably through the activation of NF‐κB and the endogenous opioid system, enhances HCV replicon expression and compromises the anti‐HCV effect of IFN‐α.”