Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
“BACKGROUND Moderate alcohol consumption associates with lower risk of type 2 diabetes, but in postprandial studies, alcohol induced impaired insulin sensitivity.”
The American journal of clinical nutrition • 2012 | View Paper
“Consumption of 30 g/d of alcohol compared with 0 g/d reduced fasting insulin concentration by 19.2% (P =.004) and triglyceride concentration by 10.3% (P =.001), and increased insulin sensitivity by 7.2% (P =.002).”
Metabolism: clinical and experimental • 1995 | View Paper
“Results showed that ethanol increased plasma and hepatic triglyceride and cholesterol content, and affected plasma levels of insulin , adiponectin, leptin, and ghrelin.”
“Further, the nutritional status is also an important component of the sometimes divergent findings pertaining to the effects of alcohol on the regulation of insulin and glucose metabolism.”
“ Chronic alcohol exposure inhibits insulin and insulin‐like growth factor signaling in the liver and brain by impairing the signaling cascade at multiple levels.”
“ Chronic ethanol consumption may improve insulin sensitivity, but the results from the randomized controlled trials are mixed.”
“Epidemiological studies have suggested that the relationship between ethanol and insulin sensitivity is either an inverted U-shape or a positive linear relationship.”
“ Ethanol and Zn(2+) were most effective when added shortly before or after insulin , indicating that all these agents facilitated cell cycle progression.”
“In serum-starved NIH 3T3 fibroblasts, ethanol (30-80 mM) promoted the effects of insulin and insulin-like growth factor I (IGF-I) on DNA synthesis in a Zn(2+)-dependent manner.”
“Of the various signal transducing events examined, ethanol stimulated cellular uptake of (45)Ca and it enhanced the stimulatory effects of insulin on p70 S6 kinase activity in a Zn(2+)-dependent manner.”
“Wiping the skin gently with absolute alcohol prior to iontophoresis resulted in a 1000-fold increase in transdermal transport of insulin relative to that across untreated skin, i.e. to almost the same level as stripping the skin.”