Possible Interaction: Ethanol and Indomethacin

“Pretreatment of animals with the cyclooxygenase inhibitor indomethacin results in a marked decrease in the protective effect of sucralfate against alcohol injury.”

“ Indomethacin markedly alters the behavioral response to ethanol , particularly in the mouse model.”

“Pretreatment with indomethacin (1 mg/kg ip) abolished the protective effects of CMR against ethanol injury.”

“Previous studies in our laboratory have demonstrated that indomethacin , a potent prostaglandin synthetase inhibitor, significantly antagonizes the depressant, activating, and hypothermic responses to ethanol.”

“These results suggest that indomethacin antagonized the effects of ethanol to an extent such that a lethal dose was transformed into a depressant dose.”

“Both indomethacin and incubation significantly reduced hypothermia induced by ethanol and pentobarbital.”

“In conclusion, indomethacin probably interferes with the mechanism for ethanol augmentation of glucose-induced insulin secretion.”

“ Indomethacin suppressed the ability of ethanol to augment insulin (P < .01) and C-peptide (P < .01) responses.”

“The patient was started on indomethacin and advised to abstain from alcohol.”

“In platelets labeled with [3H]arachidonic acid, ethanol significantly inhibited the release of arachidonic acid from phospholipids, in both the presence and the absence of indomethacin.”

“ Indomethacin dissolved in ethanol inhibited clearly the phagocytosis of S. aureus and E. coli.”

“The chronic-intermittent administration of alcohol , an animal model of BD, produced significant emotional memory impairment -blocking learning in males- which was counteracted by indomethacin , as the AI groups had similar latencies to the SS groups.”