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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Imipramine
Research Papers that Mention the Interaction
“While nefazodone failed to potentiate the sedative-hypnotic (depressant) effects of alcohol, imipramine tended to enhance them for psychomotor performance, memory assessments, and some subjective ratings.”
The effects of nefazodone, imipramine and placebo, alone and combined with alcohol, in normal subjects“An unusual case of colonic gangrene following overdose of imipramine and alcohol is presented.”
“The results of this preliminary experiment suggest that chronic ethanol exposure might affect either the synthesis of imipramine binding sites in megakaryocytes or the structural environment of imipramine binding sites in the platelet membrane.”
“Analysis of single psychoactive drug cases and single-drug-plus-ethanol cases shows that, in the presence of ethanol , the toxic blood concentration of imipramine , amytriptyline, meprobamate, thioridazine, morphine, propoxyphene, methaqualone, and all barbiturates was decreased by an average of 50%.”
“ Ethanol feeding for 4 wk induced impaired glucose tolerance compared with controls, and this was modestly improved with imipramine treatment.”
“The effect of ethanol on AMP-activated protein kinase phosphorylation was reversed by imipramine , suggesting that the generation of ceramide via acid sphingomyelinase (ASMase) is stimulated by ethanol.”
Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice.“We have observed that chronic daily exposure to a relatively high dose of alcohol can induce depressive-like behavior in rats and that pretreatment with nomifensine or imipramine can block the "depressogenic" effects of alcohol.”
“The activation of PP2A and inhibition of AMPK phosphorylation caused by ethanol was attenuated by fumonisin B1 and imipramine , an acid sphingomyelinase (SMase) inhibitor.”
“Footpad edema was evidenced in the few days after injection of both ethanol and imipramine.”
“In conclusion, a concentration of imipramine that did not affect the sinus node rate antagonized the positive chronotropic action of ethanol.”
“The investigated psychotropic drugs did not … but given in combination with ethanol caused significant decline of PD: diazepam (0.4 …%, chlorpromazine (6.7 mg/kg) by 59%, imipramine (2 mg/kg) by 48%, amitriptyline (4 mg/kg) by 49%, …/kg) by 53%, pyridinol (0.3 mg/kg) by 58%.”
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