Possible Interaction: Ethanol and Ibuprofen

“ Ibuprofen caused a 10% decrease in the maximum rate of elimination of ethanol.”

“The auditory‐verbal memory of the subjects, which is primarily a function of the left cerebral hemisphere, was assessed by the Selective Reminding Test and showed decreased impairment during combined ibuprofen and ethanol dosing as compared with ethanol dosing alone (P = 0.04).”

“Visual memory, which is a function primarily mediated by the right cerebral hemisphere, was measured by the Benton Visual Retention test and was more impaired during combined ibuprofen and ethanol dosing than during ethanol dosing alone (P = 0.05).”

“Some studies have shown that ethanol ingestion may amplify the effect of aspirin and ibuprofen on human platelets and increase risk of bleeding [6–8].”

“As the amount of ethanol was raised from 0 to 100%, ibuprofen solubility was enhanced 5,500-fold relative to its aqueous solubility.”

“In silicone membranes, the flux of ibuprofen increased 8-fold over the range of ethanol concentrations studied (0–100%) relative to aqueous solutions, with the highest flux observed for 100% ethanol.”

“Moreover, gastroprotection against ethanol damage was decreased after ibuprofen pretreatment.”

“ IBU statistically antagonized the teratogenic effects of alcohol on fetal weight and dysmorphology.”

“The obtained results suggest the conclusion that simultaneous administration of ibuprofen and ethanol causes in the mucosal gland in the proximal small intestine development of an interaction of the additive.”

“Collectively, this study has demonstrated that ibuprofen and EtOH can induce synergistic hepatotoxicity, providing a line of evidence for caution against the use of ibuprofen in combination with alcohol.”

“Higher P and removal of DCF (28.24 ± 1.10%) and IBU (18.72 ± 1.60%) with ethanol was observed for 43.20 ± 0.01 mgDCF L-1 and 43.42 ± 0.03 mgIBU L-1, respectively.”