Possible Interaction: Ethanol and Hydroxyproline

“Despite similar liver damage at these doses of CCl4, ethanol preexposure significantly enhanced indices of fibrosis (alpha smooth muscle actin [αSMA] expression, collagen staining, and hydroxyproline levels) and decreased the number of apoptotic stellate cells that were observed.”

“ Alcohol treatment markedly elevated the serum levels of aspartate transaminase, alkaline phosphatase, and total reactive oxygen species, and tissue levels of hydroxyproline and malondialdehyde (MDA), while reducing the total glutathione (GSH) contents and the activities of superoxide dismutase and catalase.”

“Hepatic content of hydroxyproline was significantly increased in ethanol plus iron-fed rats, compared with rats other than the ethanol plus iron-fed group (ethanol+iron > iron > ethanol > control).”

“In hepatocytes from starved rats, asparagine, serine, ornithine, hydroxyproline , histidine, cysteine, alanine, glycine, glutamate, glutamine, aspartate and arginine significantly increase ethanol consumption.”

“In hepatocytes from fasted rats, alanine, arginine, asparagine, aspartate, citrulline, cysteine, glutamate, glutamine, glycine, histidine, hydroxyproline , ornithine and serine increase significantly ethanol consumption.”

“ Ethanol lowered the amount of labeled proline incorporated into hydroxyproline and, therefore, into collagen.”

“ Hydroxyproline synthesis was relatively stimulated by low, but was progressively inhibited by higher, concentrations of ethanol.”