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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Ethanol and Hydromorphone

supplement:

Ethanol

Research Papers that Mention the Interaction

If Palladone capsules are broken, dissolved, crushed or taken with alcohol , the entire 24-hour dose can be released at once and could be lethal, especially in non-opioid tolerant individuals.
The Medical letter on drugs and therapeutics  •  2005  |  View Paper
The Food and Drug Agency (FDA) issued an alert in 2005 after hydromorphone was withdrawn from the market after clinical trials showed ingestion with alcohol to potentially result in lethal drug peak plasma concentrations.
Colloids and surfaces. B, Biointerfaces  •  2013  |  View Paper
In 2005, Palladone , an extended-release capsule, was withdrawn from the market after clinical testing showed subjects who took the product with alcohol had increased levels of drug in their blood.
International journal of pharmaceutics  •  2010  |  View Paper